Document Detail

Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation.
MedLine Citation:
PMID:  23454129     Owner:  NLM     Status:  MEDLINE    
Elevated levels of serum amyloid A (SAA) is a risk factor for cardiovascular diseases, however, the role of SAA in the pathophysiology of atherosclerosis remains unclear. Here we show that SAA induced macrophage foam cell formation. SAA-stimulated foam cell formation was mediated by c-jun N-terminal kinase (JNK) signaling. Moreover, both SAA and SAA-conjugated high density lipoprotein stimulated the expression of the important scavenger receptor lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) via nuclear factor-κB (NF-κB). A LOX1 antagonist carrageenan significantly blocked SAA-induced foam cell formation, indicating that SAA promotes foam cell formation via LOX1 expression. Our findings therefore suggest that SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis.
Ha Young Lee; Sang Doo Kim; Suk-Hwan Baek; Joon Hyuk Choi; Kyung-Hyun Cho; Brian A Zabel; Yoe-Sik Bae
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-27
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  433     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-05-23     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Biological Science, Sungkyunkwan University, Suwon 440-746, South Korea.
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MeSH Terms
Atherosclerosis / etiology
Carrageenan / pharmacology
Cell Differentiation / drug effects
Cell Line
Foam Cells / cytology,  drug effects,  metabolism*
Lipoproteins, HDL / metabolism,  pharmacology
MAP Kinase Signaling System
NF-kappa B / metabolism
Recombinant Proteins / genetics,  metabolism,  pharmacology
Scavenger Receptors, Class E / antagonists & inhibitors,  genetics,  metabolism*
Serum Amyloid A Protein / genetics,  metabolism*,  pharmacology
Up-Regulation / drug effects
Grant Support
Reg. No./Substance:
0/Lipoproteins, HDL; 0/NF-kappa B; 0/Olr1 protein, mouse; 0/Recombinant Proteins; 0/Scavenger Receptors, Class E; 0/Serum Amyloid A Protein; 9000-07-1/Carrageenan

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