Document Detail

Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis.
MedLine Citation:
PMID:  17344924     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the accuracy of serum amyloid A (SAA), an acute phase protein in the detection of neonatal early-onset sepsis, by means of a fast automated SAA kit. STUDY DESIGN: Full-term infants <72 h of age, who had risk factors and/or were suspected of having sepsis, were eligible for study. The levels of SAA were taken at 0, 24 and 48 h post sepsis evaluation. Thirty matched infants served as a control group for comparing SAA concentrations. RESULTS: Of 104 infants eligible for entry to the study, 23 had sepsis and 81 had not sepsis. The SAA levels of the septic group were significantly higher than those of the nonseptic group at 0, 24 and 48 h (P<0.01 for all time points). In comparison with C-reactive protein (CRP), SAA levels rose earlier and in a sharper manner, had higher levels and returned faster to normal values in infants with early onset sepsis. At 0 h post-sepsis evaluation, serum SAA had an overall better diagnostic accuracy for predicting early onset sepsis than CRP (sensitivity (96 vs 30%), specificity (95 vs 98%), positive predictive value (85 vs 78%), negative predictive value (99 vs 83%), positive likelihood ratio (19 vs 12), and negative likelihood ratio (0.05 vs 0.71). CONCLUSIONS: SSA is advocated as an inflammatory marker of neonatal early-onset sepsis.
S Arnon; I Litmanovitz; R H Regev; S Bauer; R Shainkin-Kestenbaum; T Dolfin
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Publication Detail:
Type:  Journal Article     Date:  2007-03-08
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Department of Neonatology, Meir Medical Center, Kfar-Saba, Israel.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism
Early Diagnosis
Escherichia coli Infections / blood,  diagnosis*
Infant, Newborn
Infant, Newborn, Diseases / blood,  diagnosis*
Predictive Value of Tests
Reference Values
Risk Factors
Sepsis / blood,  diagnosis
Serum Amyloid A Protein / metabolism*
Staphylococcal Infections / blood,  diagnosis*
Streptococcal Infections / blood,  diagnosis*
Streptococcus agalactiae*
Reg. No./Substance:
0/Biological Markers; 0/Serum Amyloid A Protein; 9007-41-4/C-Reactive Protein

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