| Serum amino acid concentrations in aging men and women. | |
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MedLine Citation:
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PMID: 12768504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The age and gender related differences in serum amino acid concentrations have been assessed in 72 (23-92 years) medically screened healthy men and women who were divided into three male and three female groups according to age. Free-time physical activity and food intake were analysed from the 5-day diaries. The subjects were instructed to eat according to their normal dietary habits and to avoid any clinical complementary nutritional products or other products that could increase protein or energy intake. The blood samples (5 ml) taken from the antecubital vein after an over-night fast were analysed for their amino acid contents by chromatography. In total nutrient intake of energy (P < 0.001), protein (P < 0.001), alcohol (P < 0.05), water (P < 0.01), sodium (P < 0.001) and fiber P < 0.001) decreased significantly with age. The concentration of total amino acids (P < 0.01), essential amino acids (P < 0.001), non-essential amino acids (P < 0.05) and branched-chain amino acids (P < 0.05) decreased, whereas citrulline (P < 0.001) and cysteine (P < 0.001) were the only amino acids, which increased with aging. In addition, men had significantly higher concentrations than women of essential amino acids (P < 0.001), branched-chain amino acids (P < 0.001), and 10 of the 22 individual amino acids assayed (P < 0.01). Women had significantly higher concentrations of aspartate (P < 0.05), glycine (P < 0.01), serine (P < 0.001) and taurine (P < 0.01) than men. It is concluded that the decrease in serum total amino acid concentration is associated with decreased energy and protein intake with aging and men have higher essential amino acid concentration in serum than women. |
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Authors:
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H T Pitkänen; S S Oja; K Kemppainen; J M Seppä; A A Mero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Amino acids Volume: 24 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-27 Completed Date: 2004-04-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 413-21 Citation Subset: IM |
Affiliation:
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Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / blood* Amino Acids / blood* Female Humans Male Middle Aged Sex Characteristics* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
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