Document Detail

Serum alpha-fetoprotein and neural tube defects in the first trimester of pregnancy. MRC Vitamin Study Research Group.
MedLine Citation:
PMID:  7511242     Owner:  NLM     Status:  MEDLINE    
As part of the Medical Research Council randomized trial of vitamin supplementation in the prevention of neural tube defects (NTDs), maternal serum alpha-fetoprotein (AFP) was available for 19 NTD pregnancies. Each of these was matched with four unaffected controls, by maternal age, participating centre, and duration of sample storage. The samples came from women whose gestational age ranged from 6 to 14 completed weeks. The median AFP level in the affected pregnancies was 1.2 multiples of the median value in unaffected pregnancies of the same gestational age (95 per cent confidence interval (CI) 0.83-1.59). This confirmed the view that serum AFP measurement is of no practical value in the detection of NTDs in the first trimester of pregnancy. The study also showed that folic acid supplementation, used as a method of preventing NTDs, had no effect on the concentrations of maternal serum AFP up to 14 weeks of pregnancy.
N J Wald; A Hackshaw; R Stone; J Densem
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  13     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-04-26     Completed Date:  1994-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1047-50     Citation Subset:  IM    
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St. Bartholomew's Hospital Medical College, London, U.K.
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MeSH Terms
Folic Acid / therapeutic use
Neural Tube Defects / blood*,  prevention & control
Pregnancy Trimester, First
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/alpha-Fetoproteins; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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