Document Detail

Serum alpha-fetoprotein--a biochemical indicator of prenatal hypothyroidism.
MedLine Citation:
PMID:  6194648     Owner:  NLM     Status:  MEDLINE    
Serum alpha-fetoprotein (AFP) was analysed at 10-30 days of age in infants with positive TSH screening tests for congenital hypothyroidism. These levels were significantly higher in infants with true positive screening tests than in those with false positive tests; 27 of 43 infants with congenital hypothyroidism had serum AFP levels above the age-related reference range. The postnatal rate of elimination of AFP from serum did not differ in hypothyroid and euthyroid infants, indicating that the difference in serum AFP was due to more extensive synthesis in hypothyroid individuals. The level of serum AFP was inversely correlated with the roentgenological skeletal maturation index. It is postulated that increased serum AFP is caused by prenatal hypothyroidism and that analysis of serum AFP is a valuable tool to identify those infants with congenital hypothyroidism who are at risk of neuropsychological sequelae.
A Larsson; L Hagenfeldt; L Blom; W Mortensson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  72     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  IM    
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MeSH Terms
Age Determination by Skeleton
Congenital Hypothyroidism
Hypothyroidism / blood*
Infant, Newborn
Prenatal Diagnosis*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/alpha-Fetoproteins; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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