Document Detail

Serum albumin, body weight and inflammatory parameters in chronic hemodialysis patients: a three-year longitudinal study.
MedLine Citation:
PMID:  18087147     Owner:  NLM     Status:  MEDLINE    
BACKGROUNDS AND AIMS: The present study aimed at making prospective longitudinal measurements of nutritional and inflammatory parameters to determine whether nutritional and inflammatory status decline or increase over time in a cohort of prevalent hemodialysis patients, and to evaluate which factors influence eventual changes. PATIENTS: 64 hemodialysis patients were followed at 0, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, and 36 months. At each follow-up visit, dry body weight, serum albumin, serum total cholesterol, total white blood cells, total lymphocyte count, serum glucose, C-reactive protein, ferritin, fibrinogen, hemoglobin, and weekly erythropoietin dose were assessed. MAIN OUTCOME MEASURES: Changes in nutritional and inflammatory parameters over time. RESULTS: 43 patients completed the study at 36 months. Mean serum albumin levels (g/dl) improved significantly between baseline (3.76 +/- 0.24) and 36 months (3.93 +/- 0.27) (F = 4.005; p = 0.0009). Dialytic age was significantly associated with changes of serum albumin (F = 2.797; p = 0.028). The mean dry weight slightly remained stable over time (F = 1.473; p = 1.0) as well as the level of total cholesterol (p = 0.77) and lymphocyte count (F = 1.539; p = 0.186). Over time, the levels of C-reactive protein tended to decrease, although the differences were not statistically significant (F = 1.332; p = 0.19). Over time, the serum level of fibrinogen (F = 0.422; p = 0.17) and ferritin (F = 0.314; p = 0.52) remained stable. The number of white blood cells significantly decreased over time (F = 4.691; p = 0.0079) and dialytic age (F = 3.214; p = 0.015) was the variable significantly associated with such decline. The hemoglobin levels (F = 1.423; p = 0.14) and the weekly erythropoietin dose did not change significantly during the study (F = 1.019; p = 0.61), nor did the serum glucose levels (F = 1.231; p = 0.10). CONCLUSION: These results support the hypothesis that end-stage renal disease and HD are not necessarily associated with deterioration of the nutritional status over time.
Maurizio Bossola; Giuseppe La Torre; Stefania Giungi; Luigi Tazza; Carlo Vulpio; Giovanna Luciani
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Publication Detail:
Type:  Journal Article     Date:  2007-12-14
Journal Detail:
Title:  American journal of nephrology     Volume:  28     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 S. Karger AG, Basel.
Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Rome, Italy.
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MeSH Terms
Albumins / metabolism*
Body Weight / physiology*
C-Reactive Protein / metabolism
Cholesterol / blood
Ferritins / blood
Fibrinogen / metabolism
Inflammation / physiopathology*
Kidney Failure, Chronic / blood,  physiopathology*
Longitudinal Studies
Lymphocyte Count
Middle Aged
Nutritional Status / physiology*
Prospective Studies
Time Factors
Reg. No./Substance:
0/Albumins; 57-88-5/Cholesterol; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

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