Document Detail


Serum adrenal steroid concentrations in premature infants.
MedLine Citation:
PMID:  2531155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate serum adrenal steroid concentrations in preterm infants, 17-hydroxyprogesterone (17-OHP), 17-hydroxypregnenolone, 11-deoxycortisol, cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione, 18-hydroxycorticosterone, and aldosterone values were determined in 9 sick and 13 healthy premature infants. Serum steroid concentrations were compared to previously reported data from healthy full-term infants. 17-OHP, 11-deoxycortisol, and aldosterone values were higher in sick preterm infants than in healthy preterm infants. Compared to healthy full-term infants, the premature infants-had significantly higher 17-hydroxypregnenolone, 17-OHP, and DHEA sulfate concentrations. Cortisol values were not different between the sick and healthy preterm infants and were similar to full-term values. Aldosterone values were also similar between the premature and the full-term infants. The findings of elevated steroid precursors in preterm infants and low cortisol levels in stressed sick preterm infants may indicate a relative immaturity of adrenal enzyme activity and inadequate adrenal reserve for stress.
Authors:
M M Lee; L Rajagopalan; G J Berg; T Moshang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  69     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-29     Completed Date:  1989-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1133-6     Citation Subset:  AIM; IM    
Affiliation:
Division of Endocrinology/Diabetes and Neonatology Children's Hospital, Philadelphia, Pennsylvania 19104.
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxypregnenolone / blood
17-alpha-Hydroxyprogesterone
18-Hydroxycorticosterone / blood
Aldosterone / blood
Androstenedione / blood
Birth Weight
Cortodoxone / blood
Dehydroepiandrosterone / analogs & derivatives,  blood
Dehydroepiandrosterone Sulfate
Female
Gestational Age
Hormones / blood*
Humans
Hydrocortisone / blood
Hydroxyprogesterones / blood
Infant, Newborn
Infant, Premature / blood*
Male
Steroids / blood*
Grant Support
ID/Acronym/Agency:
RR-00240/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hormones; 0/Hydroxyprogesterones; 0/Steroids; 152-58-9/Cortodoxone; 387-79-1/17-alpha-Hydroxypregnenolone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 53-43-0/Dehydroepiandrosterone; 561-65-9/18-Hydroxycorticosterone; 63-05-8/Androstenedione; 651-48-9/Dehydroepiandrosterone Sulfate; 68-96-2/17-alpha-Hydroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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