| Serum adrenal steroid concentrations in premature infants. | |
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MedLine Citation:
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PMID: 2531155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate serum adrenal steroid concentrations in preterm infants, 17-hydroxyprogesterone (17-OHP), 17-hydroxypregnenolone, 11-deoxycortisol, cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione, 18-hydroxycorticosterone, and aldosterone values were determined in 9 sick and 13 healthy premature infants. Serum steroid concentrations were compared to previously reported data from healthy full-term infants. 17-OHP, 11-deoxycortisol, and aldosterone values were higher in sick preterm infants than in healthy preterm infants. Compared to healthy full-term infants, the premature infants-had significantly higher 17-hydroxypregnenolone, 17-OHP, and DHEA sulfate concentrations. Cortisol values were not different between the sick and healthy preterm infants and were similar to full-term values. Aldosterone values were also similar between the premature and the full-term infants. The findings of elevated steroid precursors in preterm infants and low cortisol levels in stressed sick preterm infants may indicate a relative immaturity of adrenal enzyme activity and inadequate adrenal reserve for stress. |
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Authors:
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M M Lee; L Rajagopalan; G J Berg; T Moshang |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 69 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1989-12-29 Completed Date: 1989-12-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1133-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology/Diabetes and Neonatology Children's Hospital, Philadelphia, Pennsylvania 19104. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxypregnenolone
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blood 17-alpha-Hydroxyprogesterone 18-Hydroxycorticosterone / blood Aldosterone / blood Androstenedione / blood Birth Weight Cortodoxone / blood Dehydroepiandrosterone / analogs & derivatives, blood Dehydroepiandrosterone Sulfate Female Gestational Age Hormones / blood* Humans Hydrocortisone / blood Hydroxyprogesterones / blood Infant, Newborn Infant, Premature / blood* Male Steroids / blood* |
| Grant Support | |
ID/Acronym/Agency:
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RR-00240/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 0/Hydroxyprogesterones; 0/Steroids; 152-58-9/Cortodoxone; 387-79-1/17-alpha-Hydroxypregnenolone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 53-43-0/Dehydroepiandrosterone; 561-65-9/18-Hydroxycorticosterone; 63-05-8/Androstenedione; 651-48-9/Dehydroepiandrosterone Sulfate; 68-96-2/17-alpha-Hydroxyprogesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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