Document Detail

Serum adiponectin levels in patients with seasonal allergic rhinitis.
MedLine Citation:
PMID:  20188864     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A few studies have outlined a possible relationship between an increased body mass index and allergic rhinitis. A single study reported that males with seasonal allergic rhinitis (SAR), evaluated outside the pollen season, had increased serum adiponectin levels. OBJECTIVE: The aim of this preliminary study was to evaluate the serum adiponectin levels in a cohort of SAR normo-weight patients evaluated during the pollen season, comparing them with SAR patients evaluated out of pollen season and a group of healthy controls. METHODS: The study included 137 subjects; 62 SAR patients evaluated in their pollen season, while symptomatic, 41 SAR patients studied out their pollen season, while they were without symptoms, and 34 normal subjects. All subjects were consecutively evaluated. All of them were normo-weight. A skin prick test and blood sampling for assessing serum adiponectin levels were performed in all subjects. RESULTS: After analysing genders separately, symptomatic male patients had significantly higher levels than both symptomless and normal males (p=0.0041 and 0.0001 respectively), symptomatic female patients showed significantly higher levels than both symptomless and normal females (p=0.0001 and 0.0071 respectively). CONCLUSION: This study provides the preliminary evidence that adiponectin serum levels might depend on allergen exposure in SAR normo-weight patients.
Giorgio Ciprandi; Mara De Amici; Mariangela Tosca; Gianluigi Marseglia
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-02-25
Journal Detail:
Title:  International immunopharmacology     Volume:  10     ISSN:  1878-1705     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  635-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino--University of Genoa, Genoa, Italy.
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MeSH Terms
Adiponectin / blood,  immunology*
Antigens, Plant / immunology*
Body Mass Index
Middle Aged
Pilot Projects
Pollen / immunology*
Rhinitis, Allergic, Seasonal / blood,  diagnosis*,  physiopathology
Skin Tests
Reg. No./Substance:
0/Adiponectin; 0/Antigens, Plant

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