Document Detail


Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role.
MedLine Citation:
PMID:  20047566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset. It is still unclear whether hypoadiponectinemia is already present by the early stages of stroke or occurs as a delayed effect of the acute ischemic reaction. In the present study we investigated ADPN levels acutely after an IS.
MATERIALS AND METHODS: Serum ADPN was measured in 82 consecutive acute IS patients, and 30 stroke-free subjects of similar age and sex distributions.
RESULTS: Patients had significantly lower ADPN levels than controls. Higher ADPN was significantly associated with reduced odds for IS accounting for age, sex and high-density lipoproteins. This association was strengthened after further adjustments for potential confounders. ADPN levels remained suppressed even 6 months after stroke.
CONCLUSIONS: ADPN is significantly suppressed already by the early phases of stroke, and remains unchanged 6 months later. We propose a stable-over-time anti-inflammatory role of ADPN in IS, unrelated to the acute ischemic reaction.
Authors:
S Marousi; G Theodorou; M Karakantza; P Papathanasopoulos; J Ellul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-28
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  121     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-08-10     Revised Date:  2011-08-22    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  277-84     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital of Patras, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Aged
Anti-Inflammatory Agents / therapeutic use
Case-Control Studies
Female
Humans
Inflammation / metabolism
Male
Middle Aged
Stroke / blood*,  drug therapy,  physiopathology
Time Factors
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Anti-Inflammatory Agents
Comments/Corrections
Comment In:
Acta Neurol Scand. 2011 Aug;124(2):149; author reply 150   [PMID:  21732921 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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