| Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role. | |
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MedLine Citation:
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PMID: 20047566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset. It is still unclear whether hypoadiponectinemia is already present by the early stages of stroke or occurs as a delayed effect of the acute ischemic reaction. In the present study we investigated ADPN levels acutely after an IS. MATERIALS AND METHODS: Serum ADPN was measured in 82 consecutive acute IS patients, and 30 stroke-free subjects of similar age and sex distributions. RESULTS: Patients had significantly lower ADPN levels than controls. Higher ADPN was significantly associated with reduced odds for IS accounting for age, sex and high-density lipoproteins. This association was strengthened after further adjustments for potential confounders. ADPN levels remained suppressed even 6 months after stroke. CONCLUSIONS: ADPN is significantly suppressed already by the early phases of stroke, and remains unchanged 6 months later. We propose a stable-over-time anti-inflammatory role of ADPN in IS, unrelated to the acute ischemic reaction. |
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Authors:
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S Marousi; G Theodorou; M Karakantza; P Papathanasopoulos; J Ellul |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-28 |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 121 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-08-10 Revised Date: 2011-08-22 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 277-84 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital of Patras, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Aged Anti-Inflammatory Agents / therapeutic use Case-Control Studies Female Humans Inflammation / metabolism Male Middle Aged Stroke / blood*, drug therapy, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Anti-Inflammatory Agents |
| Comments/Corrections | |
Comment In:
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Acta Neurol Scand. 2011 Aug;124(2):149; author reply 150
[PMID:
21732921
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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