| Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance. | |
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MedLine Citation:
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PMID: 14688155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the relationship between resistin and insulin resistance in patients with polycystic ovary syndrome (PCOS). METHODS: We compared serum resistin levels in 17 PCOS women and 10 lean, healthy, age-matched non-PCOS women and also compared levels of insulin receptor (IR), phosphatidylinositol-3 kinase (PI3-kinase), glucose transporter 4 (GLUT4) protein and resistin mRNA in adipocytes isolated from the omental adipose tissue of five of the PCOS patients and five age- and weight-matched, non-PCOS controls, to look for local defects in insulin action in PCOS. RESULTS: The PCOS group was hyperinsulinaemic and displayed an impaired insulin response in a 75 g oral glucose tolerance test and an abnormal homeostasis model insulin resistance index. Serum resistin levels were similar in PCOS patients and controls; however, resistin mRNA levels were 2-fold higher in adipocytes from PCOS patients. No correlation was found between serum resistin levels and either the BMI or testosterone levels. Western blot analysis showed that adipocyte levels of insulin receptor, PI3-kinase, and GLUT4 were respectively decreased by 56, 39.4 and 54% in PCOS patients compared with controls. CONCLUSIONS: These results suggest that overexpression of the resistin gene in adipocytes may be a local determinant factor in the pathogenesis of PCOS. |
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Authors:
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Kok-Min Seow; Chi-Chang Juan; Liang-Yi Wu; Yung-Pei Hsu; Wei-Ming Yang; Yieh-Loong Tsai; Jiann-Loung Hwang; Low-Tone Ho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 19 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-22 Completed Date: 2004-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 48-53 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism* Adult Case-Control Studies Female Gene Expression Gonadal Steroid Hormones / blood Gonadotropins / blood Hormones, Ectopic / blood, genetics, metabolism* Humans Insulin Resistance* Polycystic Ovary Syndrome / blood, metabolism, physiopathology* RNA, Messenger / metabolism Resistin |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones; 0/Gonadotropins; 0/Hormones, Ectopic; 0/RETN protein, human; 0/RNA, Messenger; 0/Resistin |
| Comments/Corrections | |
Comment In:
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Hum Reprod. 2004 Jul;19(7):1681
[PMID:
15220312
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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