Document Detail


Serum acute phase reactants in necrotizing enterocolitis.
MedLine Citation:
PMID:  2447744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serum acute phase reactants, C-reactive protein (CRP) and orosomucoid, rose significantly within 24 to 48 hours of presentation in infants with definite necrotizing enterocolitis (NEC) compared with the levels in infants with symptoms who tolerated early reintroduction of enteral feeds. A serum CRP value greater than 10 mg/l within 48 hours identified infants with definite NEC with a 92% sensitivity and an 81% specificity. Serum CRP values remained elevated at 7 to 10 days in 4 infants with late septicaemia and in 4 of 5 infants with abscess or early stricture requiring surgery. Serum acute phase reactants are a potentially valuable adjunct to clinical assessment in the management of infants with suspected NEC.
Authors:
D Isaacs; J North; D Lindsell; A R Wilkinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  76     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-23     Completed Date:  1988-02-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  923-7     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / blood*
C-Reactive Protein / blood
Enterocolitis, Pseudomembranous / blood*,  complications,  diagnosis
Humans
Infant, Newborn
Orosomucoid / blood
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Orosomucoid; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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