| Serum activin A and inhibin A elevated in pre-eclampsia: no relation to insulin sensitivity. | |
| | |
MedLine Citation:
|
PMID: 10609725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the possible role of serum levels of activin A, inhibin A and pro-alpha inhibin (pro-alphaC) in insulin sensitivity in pre-eclampsia. DESIGN: A prospective study. SETTING: Helsinki University Central Hospital. PARTICIPANTS: Twenty-two nulliparous women with proteinuric pre-eclampsia and 16 healthy nulliparous controls in the third trimester of pregnancy. METHODS: Serum samples were collected before and after intravenous injection of glucose (0.3 g/kg) and insulin (0.03 IU/kg) (the minimal model for testing insulin sensitivity), and were assayed for activin A, inhibin A and pro-alphaC. MAIN OUTCOME MEASURES: Comparison of the levels of activin A, inhibin A and pro-alphaC between pre-eclamptic and healthy pregnant women, and the association of these proteins with insulin sensitivity. RESULTS: In pre-eclampsia elevated levels of activin A (139%, P = 0.0001), inhibin A (39%, P = 0.003), and pro-alphaC (92%, P = 0.0008) were observed. The amount of proteinuria (0.3-10.5 g/day) correlated positively with serum concentrations of activin A (P = 0.01) and inhibin A (P = 0.02). These glycoproteins were not associated with insulin sensitivity either in women with pre-eclampsia or controls. A 2.9-fold rise in blood glucose and a 52.5-fold rise in insulin during testing using the minimal model were not accompanied by any significant changes in activin A, inhibin A, and pro-alphaC. CONCLUSION: Activin A, inhibin A, and pro-alphaC are elevated in pre-eclampsia but do not appear to relate to the insulin sensitivity in pre-eclamptic or normal pregnancies. |
| | |
Authors:
|
H Laivuori; R Kaaja; U Turpeinen; U H Stenman; O Ylikorkala |
Related Documents
:
|
1426515 - Successful delivery after hepatic rupture in previous pre-eclamptic pregnancy. 7072455 - Plasma noradrenaline and adrenaline in pre-eclampsia, essential hypertension in pregnan... 17023485 - S100b protein expression in the amnion and amniotic fluid in pregnancies complicated by... 11095925 - Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae ... 15302375 - Maturation rates of vitrified-thawed immature buffalo (bubalus bubalis) oocytes: effect... 12101855 - Repeated severe neonatal hemolysis due to rhesus isoimmunization in a pregnant woman. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of obstetrics and gynaecology Volume: 106 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1999 Dec |
Date Detail:
|
Created Date: 2000-01-28 Completed Date: 2000-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1298-303 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Activins Adult Biological Markers / blood Female Gestational Age Humans Inhibins / blood* Insulin Resistance / physiology* Peptides / blood* Pre-Eclampsia / blood*, complications Pregnancy Pregnancy Trimester, Third Prenatal Care Prospective Studies Protein Precursors / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Peptides; 0/Protein Precursors; 0/inhibin-alpha subunit; 0/inhibin-alpha subunit precursor; 104625-48-1/Activins; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolated fetal echogenic intracardiac foci or golf balls: is karyotyping for Down's syndrome indicat...
Next Document: Serum markers for Down's syndrome in women who have had in vitro fertilisation: implications for ant...