Document Detail


Serum activin A and inhibin A elevated in pre-eclampsia: no relation to insulin sensitivity.
MedLine Citation:
PMID:  10609725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the possible role of serum levels of activin A, inhibin A and pro-alpha inhibin (pro-alphaC) in insulin sensitivity in pre-eclampsia. DESIGN: A prospective study. SETTING: Helsinki University Central Hospital. PARTICIPANTS: Twenty-two nulliparous women with proteinuric pre-eclampsia and 16 healthy nulliparous controls in the third trimester of pregnancy. METHODS: Serum samples were collected before and after intravenous injection of glucose (0.3 g/kg) and insulin (0.03 IU/kg) (the minimal model for testing insulin sensitivity), and were assayed for activin A, inhibin A and pro-alphaC. MAIN OUTCOME MEASURES: Comparison of the levels of activin A, inhibin A and pro-alphaC between pre-eclamptic and healthy pregnant women, and the association of these proteins with insulin sensitivity. RESULTS: In pre-eclampsia elevated levels of activin A (139%, P = 0.0001), inhibin A (39%, P = 0.003), and pro-alphaC (92%, P = 0.0008) were observed. The amount of proteinuria (0.3-10.5 g/day) correlated positively with serum concentrations of activin A (P = 0.01) and inhibin A (P = 0.02). These glycoproteins were not associated with insulin sensitivity either in women with pre-eclampsia or controls. A 2.9-fold rise in blood glucose and a 52.5-fold rise in insulin during testing using the minimal model were not accompanied by any significant changes in activin A, inhibin A, and pro-alphaC. CONCLUSION: Activin A, inhibin A, and pro-alphaC are elevated in pre-eclampsia but do not appear to relate to the insulin sensitivity in pre-eclamptic or normal pregnancies.
Authors:
H Laivuori; R Kaaja; U Turpeinen; U H Stenman; O Ylikorkala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  106     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1298-303     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Activins
Adult
Biological Markers / blood
Female
Gestational Age
Humans
Inhibins / blood*
Insulin Resistance / physiology*
Peptides / blood*
Pre-Eclampsia / blood*,  complications
Pregnancy
Pregnancy Trimester, Third
Prenatal Care
Prospective Studies
Protein Precursors / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptides; 0/Protein Precursors; 0/inhibin-alpha subunit; 0/inhibin-alpha subunit precursor; 104625-48-1/Activins; 57285-09-3/Inhibins

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