Document Detail


Serum TNF-α levels reflect the clinical severity of envenomation following a Hemiscorpius lepturus sting.
MedLine Citation:
PMID:  21411417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemiscorpius lepturus (H. lepturus), found in south-western areas of Iran and south of Iraq, is considered to be the most dangerous scorpion in the region, and poses a significant risk to the health of the indigenous population due to the unique, clinical manifestations associated with its sting.. In the present study, 36 patients from the Khuzestan province in the southwest of Iran, displaying varying degrees of envenomation following an H. lepturus scorpion sting, were admitted to hospital. Serum levels of interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α) were measured using double-ligand, enzyme-linked, immunosorbent assay (ELISA) kits, and were compared with 30 healthy controls and ten age-matched patients stung by the Mesobuthus eupeus (M. eupeus) scorpion, a less dangerous species that produces primarily neurotoxic manifestations. Blood samples from M. eupeus and H. lepturus victims were taken on admission, and from H. lepturus-stung patients six hours after serotherapy with multivalent anti-venom. When compared to healthy volunteers, with the exception of TNF-α, significantly higher serum cytokine levels were measured in patients following M. eupeus envenomation. However, all three groups of H. lepturus-stung patients showed significantly, and in a severity-related manner, higher mean values for all the interleukins that were measured, including TNF-α, when compared with M. eupeus-stung cases. Six hours after serotherapy, there was a greater reduction in cytokine and TNF-α levels in patients classed as having mild symptoms, in comparison with patients classed as having moderate to severe symptoms. The results of the present study suggest that, unlike M. eupeus, the toxic manifestations observed following being stung by H. lepturus are associated with increased serum TNF-α levels and correlate positively with the clinical severity of the symptoms. Furthermore, serotherapy is only effective when administered to mild cases of H. lepturus scorpion envenomation.
Authors:
Amir Jalali; Mohammad H Pipelzadeh; Mohammad Taraz; Ali Khodadadi; Manocher Makvandi; Edward G Rowan
Related Documents :
21365317 - Splenic mass with remote trauma history: a management dilemma.
21346697 - Graduated compression stockings to prevent venous thromboembolism in hospital: evidence...
21221497 - The association of insulin resistance and metabolic syndrome in early androgenetic alop...
14551367 - Is spironolactone safe for dialysis patients?
23422747 - Uncovering the biology of multiple myeloma among african americans: a comprehensive gen...
1483417 - Diet, body size and micronutrient status in parkinson's disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European cytokine network     Volume:  22     ISSN:  1952-4005     ISO Abbreviation:  Eur. Cytokine Netw.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-26     Revised Date:  2012-08-31    
Medline Journal Info:
Nlm Unique ID:  9100879     Medline TA:  Eur Cytokine Netw     Country:  France    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Affiliation:
Dept. of Pharmacology and Toxicology, School of Pharmacy and Toxicology Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bites and Stings / blood*,  parasitology*
Case-Control Studies
Child
Demography
Female
Humans
Male
Scorpion Venoms / blood*
Tumor Necrosis Factor-alpha / blood*
Chemical
Reg. No./Substance:
0/Scorpion Venoms; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recent trends in specular light reflectance beyond clinical fluorescence diagnosis.
Next Document:  Poultry litter incineration as a source of energy: reviewing the potential for impacts on environmen...