| Serum TGF-beta2 and TGF-beta3 are increased and positively correlated to pain, functionality, and radiographic staging in osteoarthritis. | |
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MedLine Citation:
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PMID: 20704110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this study was to verify or reject the hypothesis that systematic differences exist in various profibrotic or antifibrotic factors between osteoarthritic patients and controls, as well as between different stages of osteoarthritis. The study group comprised 63 patients with knee osteoarthritis and 18 controls. Transforming growth factor-beta (TGF-beta)1, -2, -3; tissue inhibitor of metalloproteinase (TIMP)-1 protein levels; and gelatinolytic activity of matrix metalloproteinase (MMP)-1, -2, -3, -9 activities were measured by enzyme-linked immunosorbent assay and gelatin zymography, respectively. Visual analog scale scores, Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, Lequesne clinical osteoarthritis scales, and Kellgren-Lawrence radiographic grading were recorded for each patient.Transforming growth factor-beta2 and -3 (in contrast to TGF-beta1 and TIMP-1) serum protein levels were significantly higher in osteoarthritic patients compared to controls (210%+/-14% [P<.001] and 232%+/-7% [P<10(-7)], respectively). Additionally, TGF-beta2 and -3 were strongly positively correlated to Kellgren-Lawrence radiographic grading of the disease (P<10(-5) and P<10(-7), respectively). Moreover, TGF-beta2 correlated positively with the WOMAC scale (P=.007). However, TIMP-1 decreased as osteoarthritis progressed clinically, but remained irrelevant to radiographic staging. Furthermore, activities of MMP-2 and -9, but not MMP-1+/-3, were lower in patients with osteoarthritis. |
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Authors:
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Stilianos Kapetanakis; Ioannis Drygiannakis; Kostantinos Kazakos; Nikolaos Papanas; George Kolios; Elias Kouroumalis; Dionysios-Alexandros Verettas |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-08-11 |
Journal Detail:
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Title: Orthopedics Volume: 33 ISSN: 1938-2367 ISO Abbreviation: Orthopedics Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806107 Medline TA: Orthopedics Country: United States |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Copyright Information:
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Copyright 2010, SLACK Incorporated. |
Affiliation:
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Department of Orthopedics, University Hospital of Alexandroupolis, Heraklion, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthralgia
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diagnosis*,
etiology,
physiopathology Arthrography / methods* Biological Markers / blood Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Male Middle Aged Osteoarthritis, Knee / blood*, complications, radiography Pain Measurement Prognosis Range of Motion, Articular / physiology* Severity of Illness Index Transforming Growth Factor beta2 / blood* Transforming Growth Factor beta3 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Transforming Growth Factor beta2; 0/Transforming Growth Factor beta3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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