| Serum S-100beta protein predicts brain injury after hypothermic circulatory arrest in pigs. | |
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MedLine Citation:
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PMID: 11214009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Serum S-100beta protein is suggested to be a neurobiochemical marker of brain injury after cardiac and aortic arch surgery. The aim of the present study was to investigate the predictive value of S-100beta protein with respect to histopathological analysis of the brain after a prolonged period of hypothermic circulatory arrest (HCA). METHODS: Eighteen pigs (21 to 31 kg) underwent a 75 min period of HCA at 20 degrees C. Serum concentrations of S-100beta were assayed in mixed venous blood before and 2, 4, 7 and 20 h after HCA. A semiquantitative post-mortem histopathological analysis scoring all main regions of the brain was carried out in every animal. RESULTS: All animals were stable during and after cardiopulmonary bypass (CPB) and survived at least to the first postoperative day. Ten of the 18 animals survived 7 days after surgery and were electively sacrificed. Animals with severe histopathological injury showed higher serum S-100beta protein levels at every time point after HCA. The strongest correlation between the total histopathologic score and serum S-100beta levels was found at 7 h after HCA (tau = 0.422 and p = 0.023). CONCLUSION: Serum S-100beta protein levels correlate with histopathological injury after a prolonged period of HCA in pigs. This finding supports the results of previous studies suggesting the potential accuracy of S-100beta in the prediction of brain injury after cardiac surgery. |
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Authors:
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M Pokela; V Anttila; J Rimpiläinen; J Hirvonen; V Vainionpää; K Kiviluoma; P Romsi; A Mennander; T Juvonen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 34 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-13 Completed Date: 2001-04-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: Norway |
Other Details:
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Languages: eng Pagination: 570-4 Citation Subset: IM |
Affiliation:
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Department of Surgery, Oulu University Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology Brain Damage, Chronic / blood*, pathology Calcium-Binding Proteins / blood* Cardiopulmonary Bypass / adverse effects* Female Heart Arrest, Induced* Hypothermia, Induced Nerve Growth Factors / blood* Predictive Value of Tests S100 Proteins* Swine |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins |
| Comments/Corrections | |
Comment In:
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Scand Cardiovasc J. 2000 Dec;34(6):548-9
[PMID:
11214005
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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