| Serum IgA/C3 Ratio Predicts progression of IgA Nephropathy. | |
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MedLine Citation:
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PMID: 23134230 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The serum IgA/C3 ratio has been shown to be a good predictor of histological lesions and prognosis for patients with IgA nephropathy (IgAN) in Japanese. But its validity in Chinese population is unclear. We sought to explore the long-term outcomes of IgAN, its clinical and histopathological predictors in Chinese patients. In particular, the role of serum IgA/C3 ratio in the course of IgAN was addressed. METHODS: A total of 217 biopsy-diagnosed IgAN patients were recruited into this prospective cohort with a mean follow-up of 36(25th-75th percentile, 27-48) months. Sociodemographics, serum IgA/C3 level, other clinical examinations, and Lee's histological grade were measured. The patients with a decline of eGFR> 50% or developing End-stage renal disease (ESRD) were defined as progression. RESULTS: A total of 21 patients were found to progress (9.7%). In multivariate analysis, renal end point of IgAN was significantly predicted by Proteinuria ≥1 g/day (RR = 2.65, 95% CI 1.01-7.68), hypertension (RR = 3.15, 95% CI 1.07-9.29), higher Lee's histological grade (RR = 4.67, 95% CI 1.43-15.25), and serum IgA/C3 ratio≥3.32 (RR = 4.31, 95% CI 1.33-13.96). CONCLUSION: A proportion of patients with IgAN developed end stage renal disease in Chinese. In addition to some traditional risk factors, we also confirmed that IgA/C3 ratio is a useful predictor of poor outcomes of IgAN in Chinese patients. |
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Authors:
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Jun Zhang; Chen Wang; Ying Tang; Hui Peng; Zeng-Chun Ye; Cui-Cui Li; Tan-Qi Lou |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
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Title: Nephrology (Carlton, Vic.) Volume: - ISSN: 1440-1797 ISO Abbreviation: Nephrology (Carlton) Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9615568 Medline TA: Nephrology (Carlton) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author. Nephrology © 2012 Asian Pacific Society of Nephrology. |
Affiliation:
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Department of Nephrology, 3rd Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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