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Serum IgA/C3 Ratio Predicts progression of IgA Nephropathy.
MedLine Citation:
PMID:  23134230     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The serum IgA/C3 ratio has been shown to be a good predictor of histological lesions and prognosis for patients with IgA nephropathy (IgAN) in Japanese. But its validity in Chinese population is unclear. We sought to explore the long-term outcomes of IgAN, its clinical and histopathological predictors in Chinese patients. In particular, the role of serum IgA/C3 ratio in the course of IgAN was addressed. METHODS: A total of 217 biopsy-diagnosed IgAN patients were recruited into this prospective cohort with a mean follow-up of 36(25th-75th percentile, 27-48) months. Sociodemographics, serum IgA/C3 level, other clinical examinations, and Lee's histological grade were measured. The patients with a decline of eGFR> 50% or developing End-stage renal disease (ESRD) were defined as progression. RESULTS: A total of 21 patients were found to progress (9.7%). In multivariate analysis, renal end point of IgAN was significantly predicted by Proteinuria ≥1 g/day (RR = 2.65, 95% CI 1.01-7.68), hypertension (RR = 3.15, 95% CI 1.07-9.29), higher Lee's histological grade (RR = 4.67, 95% CI 1.43-15.25), and serum IgA/C3 ratio≥3.32 (RR = 4.31, 95% CI 1.33-13.96). CONCLUSION: A proportion of patients with IgAN developed end stage renal disease in Chinese. In addition to some traditional risk factors, we also confirmed that IgA/C3 ratio is a useful predictor of poor outcomes of IgAN in Chinese patients.
Authors:
Jun Zhang; Chen Wang; Ying Tang; Hui Peng; Zeng-Chun Ye; Cui-Cui Li; Tan-Qi Lou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. Nephrology © 2012 Asian Pacific Society of Nephrology.
Affiliation:
Department of Nephrology, 3rd Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
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