| Serum Procalcitonin Levels in Patients With Myeloperoxidase-Antineutrophil Cytoplasmic Antibodies-Associated Glomerulonephritis. | |
| | |
MedLine Citation:
|
PMID: 21817883 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION:: High serum procalcitonin (PCT) levels (≥0.5 ng/mL) commonly occur with systemic bacterial and fungal infections. Although several studies suggested that measuring serum PCT levels may serve as a useful marker to distinguish between active antineutrophil cytoplasmic antibodies (ANCA)-associated diseases and invasive infections, there is no information on PCT in myeloperoxidase (MPO)-ANCA-associated glomerulonephritis. METHODS:: The authors measured serum PCT concentrations before initiation of immunosuppressive therapy in 67 patients with biopsy-proven MPO-ANCA-associated glomerulonephritis. The authors compared complications and clinicopathological parameters between patients with serum PCT levels of <0.5 ng/mL (group A: 58 patients) and ≥0.5 ng/mL (group B: 9 patients). RESULTS:: All 58 patients in group A did not show any clinical sign of systemic infection. On the other hand, 3 of 9 patients in group B had bacterial or fungal infections of the respiratory or urinary tact. One patient had a history of chronic urinary tract infection. In the remaining 5 patients in group B, there were 3 patients with concurrent malignancies and 1 postoperative patient with malignancy. Another in group B had a long history of interstitial pneumonia of unknown origin and severe renal insufficiency. Serum levels of C-reactive protein and creatinine were significantly higher in group B than in group A. CONCLUSIONS:: In patients with MPO-ANCA-associated glomerulonephritis, serum PCT levels of ≥0.5 ng/mL are recommended as cutoff for consideration of bacterial and fungal infections. Elevated serum PCT levels could also be observed in some patients with severe injury of the kidneys and/or lungs in the absence of infection. |
| | |
Authors:
|
Atsushi Komatsuda; Ayumi Omokawa; Takashi Fujiwara; Ryuta Sato; Masaru Togashi; Shin Okuyama; Ken-Ichi Sawada; Hideki Wakui |
Related Documents
:
|
16739553 - Inspiratory muscle pacing in spinal cord injury: case report and clinical commentary. 22112693 - Arterial cerebrovascular complications in 94 adults with acute bacterial meningitis. 15125053 - Tremor in parkinson's disease: 24-hr monitoring with calibrated accelerometry. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Is Methicillin-Resistant Staphylococcus aureus Pneumonia Epidemiology and Sensitivity Changing?
Next Document: Implementing National Institute of Clinical Excellence Guidelines for Venous Thromboembolism Prophyl...