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Serum Preadipocyte Factor-1 is Increased in Fetuses of Pregnancy Complicated with Severe Preeclampsia.
MedLine Citation:
PMID:  23810563     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Preadipocyte factor-1(Pref-1), an inhibitor of adipocyte differentiation, is increased in fetal blood of small for gestational age (SGA) and is considered a factor involved in determining adiposity and associated with high risk of metabolic diseases in adulthood. Preeclampsia is a condition closely associated with SGA, however, the alteration of Pref-1 of in fetuses of preeclampsia remains unknown. The aims of the current investigation were to clarify the alteration of serum Pref-1 in fetuses of preelamptic pregnancy and to explore possible role of Pref-1 in metabolic diseases in late life.
METHODS: Cord blood samples were taken at birth from 45 fetuses of normal pregnancy, 16 of gestational hypertension, 29 of mild preeclampsia and 29 of severe preeclampsia. Serum Pref-1 concentrations were measured with ELISA.
RESULTS: There were significant differences in cord blood Pref-1 and neonatal birth weight among normal pregnancy, gestational hypertension, mild and severe preeclampsia (F=8.557, P<0.001 for pref-1; F=38.405, P<0.001 for birth weight). Serum pref-1 was significantly higher while birth weight were lower in severe preeclampsia than normal pregnancy, gestational hypertension and mild preeclampsia respectively (P<=0.001 for all). However, either serum pref-1 or birth weight did not significantly differ among normal pregnancy, gestational hypertension and mild preeclampsia (P>0.05 for all). Fetal pref-1 concentration was significantly negatively correlated with birth weight (R(2)=0.175, P=0.027 for severe preeclampsia; R(2)=0.209, P<0.001 for preeclampsia; R(2)=0.25, P<0.001 for all subjects).
CONCLUSIONS: Increased serum pref-1 was demonstrated in fetuses of preeclampsia- complicated pregnancy, and it may be proposed that pref-1 is among the possible mediators leading to high risk of metabolic diseases in adulthood.
Authors:
Qunyan Zhou; Jie Li; Hanzhi Wang; Cong Han; Ting Tian; Qiuyuan Zhu; Hefeng Huang; Minyue Dong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-25
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education.
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