Document Detail

Serum PCB profiles in Native Americans from Wisconsin based on region, diet, age, and gender: Implications for epidemiology studies.
MedLine Citation:
PMID:  15935445     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Different PCB congeners and different mixtures of congeners have been demonstrated to have different biological actions. More complete characterization of congener profiles in exposure sources may assist in predicting health outcomes. METHODS: Thirty-six (36) polychlorinated biphenyl (PCB) congeners were measured by gas chromatography isotope-dilution mass spectrometry (IDMS) in 314 serum samples from Native Americans in Wisconsin, Michigan and Minnesota. Five dietary groups were established based on the quantity and species of fish consumed and the waters from which the fish were caught. Multivariate statistical methods were able to resolve gender and dietary differences in PCB homologue and PCB congener patterns. RESULTS: Females had higher proportions of lower chlorinated homologues, including a consistently higher proportion of pentaCB 118. The relative presence of the very labile and volatile PCB 18, above 1% of the total PCB in females from the minimal fish consumption and "other" groups, suggests possible exposure to PCBs in the atmosphere. The dietary group consuming predatory fishes from Lakes Michigan and Superior had the highest serum concentrations of total PCB (mean of 3.1 ng/ml) and the most distinct congener profile. The two dietary groups least dependent on fishing or fishing mostly from inland lakes (non-Great Lakes) had the lowest total PCB concentrations, both with means of 1.4 ng/ml. CONCLUSIONS: These serum PCB concentrations were less than those found in earlier studies of fish consumers in the Great Lakes region and may reflect the decrease in PCBs in these lakes.
David J Schaeffer; John A Dellinger; Larry L Needham; Larry G Hansen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2005-06-01
Journal Detail:
Title:  The Science of the total environment     Volume:  357     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-05-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  74-87     Citation Subset:  IM    
Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.
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MeSH Terms
Age Factors
Environmental Monitoring
Environmental Pollutants / blood*
Epidemiologic Studies
Food Contamination*
Indians, North American
Multivariate Analysis
Polychlorinated Biphenyls / blood*
Sex Factors
Wisconsin / epidemiology
Grant Support
H75/ATH570080//PHS HHS
Reg. No./Substance:
0/Environmental Pollutants; 0/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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