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Serum Neutrophil Gelatinase-Associated Lipocalin as a marker of Acute Kidney Injury in Asphyxiated Neonates.
MedLine Citation:
PMID:  23255690     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To determine the clinical utility of serum neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in asphyxiated neonates with hypoxic ischemic encephalopathy(HIE). DESIGN: Cohort study. SETTINGS: NICU of Maternity Hospital, Ain Shams University, Cairo, Egypt. PATIENTS: The study included 30 term asphyxiated neonates (8 with mild, 13 with moderate and 9 with severe HIE) and 20 control neonates. INTERVENTION: None. MAIN OUTCOME MEASURES: Serum NGAL level was measured within 6 hours after birth using an enzyme linked immunosorbent assay. Patients were subsequently discriminated into AKI (n=12) and no-AKI (n=18) groups. Results: The median (Interquartile range) serum NGAL concentration was 95.0 (70.75-180.00) ng/ml in asphyxiated neonates, 39.75 (6.0-48.0) ng/ml in control neonates; (p<0.001). Serum NGAL correlated with HIE severity: mean (SD) was 65.50 (3.77) ng/ml in infants with mild HIE, 115.07 (45.83) ng/ml in infants with moderate HIE and 229.66 (79.50) ng/ml in infants with severe HIE; (p<0.01). The median (Interquartiles) serum NGAL level was 182.50 (166.25-301.75) ng/ml in patients with AKI, 74.00 (66.00-78.75) ng/ml in those without AKI; (p<0.001). A cutoff value 157 ng/ml for serum NGAL could detect AKI in asphyxiated neonates with a sensitivity of 83.3% and a specificity of 94.4%. CONCLUSION: Elevated serum NGAL measured within 6 hours after birth reliably indicates acute kidney injury in asphyxiated neonates.
Authors:
N M El Raggal; S M Khafagy; N H Mahmoud; S A El Beltagy
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-05
Journal Detail:
Title:  Indian pediatrics     Volume:  -     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Pediatrics, and Clinical Faculty of Medicine Ain Shams University, Egypt. Correspondence to: Dr. Soha Mohamed Khafagy, Pediatric Department, Ain Shams University, Abbassayia Cairo, Egypt. Soha_khafagy@yahoo.com.
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