Document Detail

Serum Neuron-specific Enolase Levels in Preterm and Term Newborns and in Infants 1-3 Months of Age.
MedLine Citation:
PMID:  25315754     Owner:  NLM     Status:  Publisher    
BACKGROUND: Elevated serum levels of neuron-specific enolase (NSE) was initially assumed to be specific to neuronal tumors (particularly neuroblastoma), but is now known to accompany nontumoral conditions and tumors other than neuroblastomas. There is a need to establish normal ranges for NSE, especially in early infancy. The aims of this study were to determine reference values for NSE in newborns and young infants and to assess whether NSE levels in early infancy (i.e., preterm infants and term infants) differ from the adult reference range for this enzyme.
METHODS: We enrolled 140 healthy babies, which included 40 preterm newborns (3-15 days old and born at 28-42 weeks gestation), 40 term newborns (< 1 month old and born at term), and 60 young infants 1-3 months old (n = 20 per subgroup of 1-, 2-, and 3-month-old infants). The determination of NSE levels was performed by the electrochemiluminescence immunoassay (ECLIA) method using the Elecysys 2010 device (Roche Diagnostics, Mannheim, Germany). The mean serum NSE levels for the preterm newborns was 21.83 ± 15.06 ng/mL [95% confidence interval (95%CI), 16.95-26.71 ng/mL]; term newborns, 18.06 ± 12.83 ng/mL (95%CI, 13.94-22.19 ng/mL); and young infants, 9.09 ± 4.38 ng/mL (95%CI, 7.96-10.23 ng/mL). The mean serum NSE level for infants 1-3 months old was within the ECLIA kit's normal range (4.7-18 ng/mL for adults), whereas the corresponding means for the preterm and term newborns were higher (p < 0.001, for both).
CONCLUSION: Our findings suggest that adult reference values should not be applied to the preterm and term age groups.
Aslihan Abbasoglu; Faik Sarialioglu; Nalan Yazici; Nilufer Bayraktar; Aysegul Haberal; Ayse Erbay
Related Documents :
9009454 - Cultural issues in death and dying.
23946334 - Is limitation of hip abduction a useful clinical sign in the diagnosis of developmental...
9469874 - Lipid content and time-to-death-dependent lethal body burdens of naphthalene and 1,2,4-...
24606114 - Viral aetiology and clinical outcomes in hospitalised infants presenting with respirato...
10400554 - Prevalence and determinants of prone sleeping position in infants: results from two cro...
10355314 - Nutrition of honduran mothers/caretakers.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-11
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  -     ISSN:  1875-9572     ISO Abbreviation:  Pediatr Neonatol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-15     Completed Date:  -     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of foraging and Gp-9 are associated with social organization in the fire ant Solenopsis i...
Next Document:  Comparison of Wright's Formula and the Dunn Method for Measuring the Umbilical Arterial Catheter Ins...