Document Detail

Serum midkine as a predictor of cardiac events in patients with chronic heart failure.
MedLine Citation:
PMID:  20350697     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Midkine, a heparin-binding growth factor, has various functions such as migration of inflammatory cell and anti-apoptotic effect. Invasion of inflammatory cell and cardiomyocyte apoptosis are involved in development and progression of heart failure (HF). However, the relationship between midkine and HF has not been previously examined. Therefore, we examined clinical significance of serum midkine levels to determine the prognosis of HF patients. METHODS AND RESULTS: Serum levels of midkine were measured at admission in 216 consecutive patients hospitalized for HF and 60 control subjects. Patients were prospectively followed during a mean follow-up period of 653 +/- 375 days with the end points of cardiac death and progressive HF requiring rehospitalization. Serum concentrations of midkine were significantly higher in patients with HF than in controls. Patients with cardiac events had significantly higher concentrations of midkine than those without cardiac events. Kaplan-Meier analysis revealed that cardiac event rates increased markedly as midkine levels rose. Furthermore in the multivariate analysis, after adjustment for age, gender ,and complications, midkine was the independent predictor of cardiac events. CONCLUSION: Serum midkine levels are increased in HF patients, and midkine is a novel marker for risk stratifying HF patients.
Tatsuro Kitahara; Tetsuro Shishido; Satoshi Suzuki; Shigehiko Katoh; Toshiki Sasaki; Mitsunori Ishino; Joji Nitobe; Takuya Miyamoto; Takehiko Miyashita; Tetsu Watanabe; Yasuchika Takeishi; Isao Kubota
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Journal of cardiac failure     Volume:  16     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Cardiovascular Diseases / blood,  mortality,  physiopathology
Chronic Disease
Cytokines / blood*,  diagnostic use
Diastole / physiology
Heart Failure / blood*,  mortality,  physiopathology*
Middle Aged
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Risk Factors
Survival Rate / trends
Systole / physiology
Ventricular Dysfunction, Left / blood,  mortality,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 137497-38-2/midkine

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