Document Detail

Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.
MedLine Citation:
PMID:  20216099     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Biliary atresia (BA) is the most serious liver disease in infants. Diagnosis currently depends on surgical exploration of the biliary tree. Noninvasive tests that distinguish BA from other types of neonatal liver disease are not available.
PATIENTS AND METHODS: To identify potential serum biomarkers that classify children with neonatal cholestasis, we performed 2-dimensional difference gel electrophoresis, statistical analysis, and tandem mass spectrometry using serum samples from 19 infants with BA and 19 infants with non-BA neonatal cholestasis.
RESULTS: Eleven potential serum biomarkers were found that could in combination classify children with neonatal cholestasis.
CONCLUSIONS: Although no single biomarker or imaging test adequately distinguishes BA from other types of neonatal cholestasis, combinations of biomarkers, imaging tests, and noninvasive clinical criteria should be further explored as potential tests for rapid and accurate diagnosis of BA.
Hongtao Wang; James P Malone; Petra Erdmann Gilmore; Alan E Davis; John C Magee; R Reid Townsend; Robert O Heuckeroth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  50     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-08-19     Revised Date:  2012-07-02    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-6     Citation Subset:  IM    
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
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MeSH Terms
Biliary Atresia / blood,  diagnosis*
Biological Markers / blood
Blood Proteins / analysis*
Child, Preschool
Cholestasis / blood,  diagnosis*
Diagnosis, Differential
Electrophoresis, Gel, Two-Dimensional
Infant, Newborn
Infant, Newborn, Diseases / blood,  diagnosis*
Tandem Mass Spectrometry
Grant Support
P30 DK052574-11/DK/NIDDK NIH HHS; P30 DK52574/DK/NIDDK NIH HHS; P41 RR000954-296550/RR/NCRR NIH HHS; P41RR000954/RR/NCRR NIH HHS; R21 DK068371-01/DK/NIDDK NIH HHS; R21 DK68371/DK/NIDDK NIH HHS; U01 DK062456/DK/NIDDK NIH HHS; U01 DK062456/DK/NIDDK NIH HHS; U01 DK062456-05/DK/NIDDK NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins

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