Document Detail


Serum magnesium, ambulatory blood pressure, and carotid artery alteration: the Ohasama study.
MedLine Citation:
PMID:  20706194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.
METHODS: sMg and ABP, monitored every 30 min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used.
RESULTS: Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80 mm Hg), lower sMg levels (<2.2 mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of ≥2 carotid plaques (OR, 2.14; 95% confidence interval, 1.18-3.85; P = 0.01).
CONCLUSIONS: Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.
Authors:
Takanao Hashimoto; Azusa Hara; Takayoshi Ohkubo; Masahiro Kikuya; Yoriko Shintani; Hirohito Metoki; Ryusuke Inoue; Kei Asayama; Atsuhiro Kanno; Manami Nakashita; Shiho Terata; Taku Obara; Takuo Hirose; Haruhisa Hoshi; Kazuhito Totsune; Hiroshi Satoh; Yutaka Imai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-12
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-03-03     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1292-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases / etiology
Carotid Arteries / pathology,  ultrasonography*
Carotid Artery Diseases / blood,  pathology*
Cross-Sectional Studies
Female
Humans
Magnesium / blood*
Male
Middle Aged
Tunica Intima / pathology
Chemical
Reg. No./Substance:
7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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