Document Detail

Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients.
MedLine Citation:
PMID:  2967127     Owner:  NLM     Status:  MEDLINE    
Although the serum lipoprotein fraction Lp(a) has been associated with coronary artery atherosclerosis, its relationship to narrowing of saphenous vein grafts has not previously been elucidated. We therefore measured serum Lp(a) levels in 167 symptomatic patients undergoing cardiac catheterization who had had coronary artery bypass surgery 0.7 to 14.3 years earlier. Lp(a), total cholesterol, and total triglyceride levels were compared with the degree of saphenous vein graft stenosis to test for any association. Serum Lp(a) levels were significantly associated with the degree of stenosis of saphenous vein grafts (r = .24, p = .002). Mean Lp(a) levels (mg/dl) in the 135 patients with stenosis were almost double (32.0 +/- 32.7, mean +/- SD) those in the 32 patients with no graft stenosis (16.7 +/- 22.6; p = .002). Graft stenosis was not associated with previous myocardial infarction, hypertension, obesity, diabetes, or smoking. Serum cholesterol levels (mg/dl) were slightly higher in the stenosis group (251.3 +/- 69) than in the no-stenosis group (231.8 +/- 48.8), but the difference was of borderline significance (p = .06). A stepwise increase in mean Lp(a) was found in groups of patients with increasing vein graft stenosis. At a serum Lp(a) level of 31.6 mg/dl or above, 92% of the patients demonstrated vein graft stenosis. Thus, patients with elevated Lp(a) levels have an increased risk of developing saphenous vein graft stenosis after coronary bypass surgery.
H F Hoff; G J Beck; C I Skibinski; G Jürgens; J O'Neil; J Kramer; B Lytle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  77     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-28     Completed Date:  1988-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1238-44     Citation Subset:  AIM; IM    
Department of Brain, Research, Cleveland Clinic Foundation, OH 44106.
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MeSH Terms
Coronary Angiography
Coronary Artery Bypass*
Cross-Sectional Studies
Graft Occlusion, Vascular / blood,  diagnosis*
Heart Catheterization
Lipids / blood
Lipoproteins / blood*
Middle Aged
Regression Analysis
Risk Factors
Saphenous Vein / transplantation
Time Factors
Grant Support
Reg. No./Substance:
0/Lipids; 0/Lipoprotein(a); 0/Lipoproteins

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