| Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. | |
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MedLine Citation:
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PMID: 20032478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to examine the effect of a quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of 93 overweight-obese volunteers aged 25-65 y with metabolic syndrome traits in relation to apolipoprotein (apo) E genotype. Participants were randomized to receive 150 mg/d quercetin in a double-blinded, placebo-controlled, crossover trial with 6-wk treatment periods separated by a 5-wk washout period. Retrospectively, 5 apoE genotype variants were found (epsilon2/epsilon3, n = 3; epsilon3/epsilon3, n = 60; epsilon3/epsilon4, n = 23; epsilon2/epsilon4, n = 4; and epsilon4/epsilon4, n = 3). Participants were classified into the following 3 apoE phenotypes: apoE2 (n = 3), apoE3 (n = 60), and apoE4 (n = 26). Data were analyzed for apoE3 and apoE4 subgroups. Quercetin decreased systolic blood pressure by 3.4 mm Hg (P < 0.01) in the apoE3 group, whereas no significant effect was observed in the apoE4 group. Quercetin decreased serum HDL cholesterol (P < 0.01) and apoA1 (P < 0.01) and increased the LDL:HDL cholesterol ratio (P < 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables. Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found. Serum C-reactive protein and nutritional status (body weight, waist circumference, fat mass, fat-free mass) were unaffected compared with placebo. In conclusion, quercetin exhibited blood pressure-lowering effects in overweight-obese carriers of the apo epsilon3/epsilon3 genotype but not in carriers of the epsilon4 allele. Furthermore, quercetin supplementation resulted in a reduction in HDL cholesterol and apoA1 in apo epsilon4 carriers. |
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Authors:
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Sarah Egert; Christine Boesch-Saadatmandi; Siegfried Wolffram; Gerald Rimbach; Manfred J Müller |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 278-84 Citation Subset: IM |
Affiliation:
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Institute of Nutrition and Food Science, Nutritional Physiology, University of Bonn, 53115 Bonn, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / pharmacology*, therapeutic use Apolipoproteins E / blood, genetics* Blood Pressure / drug effects*, genetics Cholesterol, HDL / blood, genetics Cholesterol, LDL / drug effects, genetics Cross-Over Studies Double-Blind Method Female Humans Male Middle Aged Obesity / blood, drug therapy, genetics* Phenotype Phytotherapy Plant Extracts / pharmacology*, therapeutic use Polymorphism, Single Nucleotide* Quercetin / pharmacology*, therapeutic use Tumor Necrosis Factor-alpha / blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 117-39-5/Quercetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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