Document Detail

Serum levels of thiobarbituric acid-reactive substances are associated with risk of coronary heart disease.
MedLine Citation:
PMID:  21427508     Owner:  NLM     Status:  MEDLINE    
AIM: Evidence of relationships between lipid peroxidation and the incidence of coronary heart disease is limited. We therefore investigated this association in a Japanese general population.
METHODS: We prospectively studied 1945 individuals who were apparently healthy at the baseline. Cox proportional-hazards models were used to investigate the relationship between serum levels of thiobarbituric acid-reactive substances (TBARS) as a marker of lipid peroxidation and the incidence of coronary heart disease, adjusted for established risk factors including age, sex, current smoking, body mass index, systolic blood pressure, glycohemoglobin A1c, serum total cholesterol, and serum high-density lipoprotein cholesterol levels.
RESULTS: During 20,226 person-years of follow-up (median follow-up, 10.9 years), 44 coronary events were documented. The risk of coronary heart disease increased in consecutive tertiles of the TBARS level. On age-and sex-adjusted analysis, the level of TBARS was significantly associated with the incidence of coronary heart disease. The hazard ratio in the highest tertile compared with the lowest tertile was 3.22 (95% confidence interval, 1.38 to 7.53; p= 0.007). On multivariate analysis adjusted for age, sex, and other established risk factors, this association remained significant (hazard ratio, 3.23; 95% confidence interval, 1.28 to 8.16; p= 0.01).
CONCLUSIONS: Serum levels of TBARS are a strong and independent predictor of coronary heart disease. These findings support the hypothesis that lipid peroxidation is an important risk factor for coronary heart disease.
Shin-Ichiro Tanaka; Tetsuo Miki; Shoto Sha; Ken-Ichi Hirata; Yuichi Ishikawa; Mitsuhiro Yokoyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-18
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  18     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-12-14     Revised Date:  2011-12-15    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  584-91     Citation Subset:  IM    
Department of Internal Medicine, Toyooka Hospital Hidaka Medical Center, Hyogo, Japan.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Body Mass Index
Cohort Studies
Coronary Disease / blood*
Lipid Peroxidation
Lipoproteins, HDL / blood
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Thiobarbituric Acid Reactive Substances / metabolism*
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Thiobarbituric Acid Reactive Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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