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Serum Levels of Long-chain Polyunsaturated Fatty Acids in Patients with Periodontal Disease.
MedLine Citation:
PMID:  22769444     Owner:  NLM     Status:  Publisher    
Background: Long chain polyunsaturated fatty acids Omega-3 and -6 (LC-PUFA n-3 n-6) can function as important inflammatory modulators and also have a strong effect in the proresolving inflammatory processes. Aim: Our aim was to analyze the serum levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and arachidonic acid (AA) in generalized chronic periodontitis patients and compare these results with serum levels of patients with gingivitis alone. Material and methods: Twenty one patients with untreated generalized chronic periodontitis (GCP) (mean age 46.0 ± 8.8) and 16 patients with gingivitis only (mean age 31.5 ± 7.5) were investigated. The clinical examination included probing depth (PD), clinical attachment level, bleeding on probing and plaque index. Blood samples were analyzed for the presence of DHA, EPA, DPA and AA using gas chromatograph. Results: Significantly higher levels of DHA, DPA, EPA and AA were observed in GCP patients when compared to gingivitis (p= 0.007, 0.004, 0.033 and 0.001, respectively). The differences were still significant even after the adjustments for age and gender. The PD showed a significant positive correlation with DHA (r = 0.5, p= 0.003), DPA (r = 0.6, p< 0.001) and AA (r = 0.6, p< 0.001). Conclusion: The present findings suggest that serum levels of n-3 and n-6 LC-PUFA may be affected by the severity of periodontal disease.
Carlos Marcelo Figueredo; Gisele L Martinez; Josely C Koury; Ricardo G Fischer; Anders Gustafsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Odontology, Departament of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
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