| Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage. | |
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MedLine Citation:
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PMID: 21727995 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Fatty acid synthase is a common phenotype to various human cancers including those of prostate, colon, lung, endometrium, and stomach. Increased fatty acid synthase levels have been detected in serum from patients with breast and pancreatic cancer. In this study, serum levels of fatty acid synthase were measured in colorectal cancer patients at different stages of disease. METHODS: Consecutive 67 patients with colorectal cancer were enrolled in the study. Serum levels of fatty acid synthase were examined by ELISA test. The Kruskal-Wallis test and the χ (2) method for trend have been used to analyze data. RESULTS: Serum fatty acid synthase levels of patients belonging to three groups of stage disease are statistically different. The patients with stage III and IV have significantly higher serum levels of fatty acid synthase than patients with stage I-II. There is a positive trend in serum fatty acid synthase levels from stage I-II to stage III and IV of disease. CONCLUSIONS: Fatty acid synthase levels are associated with the stage of disease in patients with colorectal cancer. |
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Authors:
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Maria Notarnicola; Valeria Tutino; Menotti Calvani; Dionigi Lorusso; Vito Guerra; Maria Gabriella Caruso |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-5 |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: - ISSN: 1941-6636 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Biochemistry, National Institute for Digestive Diseases, Castellana Grotte, Bari, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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