| Serum Levels of Calcitonin Gene-related Peptide and Substance P are Decreased in Patients with Diabetes Mellitus and Coronary Artery Disease. | |
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MedLine Citation:
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PMID: 22429353 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: This study evaluated serum levels of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in coronary artery disease (CAD) patients with and without a history of diabetes mellitus (DM). METHODS: Patients undergoing coronary angiography for suspected myocardial ischaemia were divided into four groups depending on their clinical status: control group (no CAD or DM; n = 44), DM group (DM without CAD; n = 46), CAD group (stable CAD without DM; n = 44) and DM + CAD group (stable CAD with DM; n = 50). Serum levels of CGRP and SP were determined using radioimmunoassays. RESULTS: CGRP and SP levels in the DM and CAD groups were significantly lower than in the control group. The lowest levels of CGRP and SP were observed in the DM + CAD group. There were no significant differences in CGRP and SP levels between the DM group and the CAD group. CONCLUSION: CGRP and SP may have a role in the pathogenesis of CAD in patients with diabetes. |
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Authors:
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L H Wang; S X Zhou; R C Li; L R Zheng; J H Zhu; S J Hu; Y L Sun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 40 ISSN: 1473-2300 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 134-40 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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