| Serum leptin, adiponectin and tumor necrosis factor-α in hyperlipidemic rats with/without concomitant diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 20838752 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12 wks. Groups B and D received a high-fat diet enriched with 2% additional cholesterol. Moreover, insulin-deficient (type I) diabetes mellitus was induced in rats in groups C and D with intraperitoneal injections of streptozotocin. Fasting serum leptin levels were decreased in diabetic groups (groups C and D) compared with controls. Fasting serum adiponectin levels were decreased in groups C and D compared with group A. Serum TNF-α levels were augmented in groups B and D, those fed with an atherogenic diet. By contrast, TNF-α levels were decreased in group C. Our data suggest that serum leptin, adiponectin and TNF-α levels may serve as markers of obesity and type I diabetes mellitus. |
| | |
Authors:
|
Angeliki Margoni; Despoina N Perrea; Ioannis Vlachos; Georgia Prokopaki; Alkistis Pantopoulou; Lambros Fotis; Maria Kostaki; Athanasios G Papavassiliou |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
|
Title: Molecular medicine (Cambridge, Mass.) Volume: 17 ISSN: 1528-3658 ISO Abbreviation: Mol. Med. Publication Date: 2011 Jan-Feb |
Date Detail:
|
Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9501023 Medline TA: Mol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 36-40 Citation Subset: IM |
Affiliation:
|
Department of Biological Chemistry, University of Athens Medical School, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloprote...
Next Document: Publication in a Brazilian journal by Brazilian scientists whose papers have international impact.