Document Detail

Serum L-homoarginine concentration is elevated during normal pregnancy and is related to flow-mediated vasodilatation.
MedLine Citation:
PMID:  18802314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Normal pregnancy is associated with enhanced vasodilatation because of the increased nitric oxide (NO) production. Because L-homoarginine can act as a substrate for NO production, concentrations of L-homoarginine in normal pregnancy were assessed in the present study to test whether L-homoarginine is associated with endothelial function. METHODS AND RESULTS: Healthy non-pregnant (n=61) and pregnant women (n=58) were studied in a cross-sectional study. L-homoarginine, L-arginine, asymmetric dimethylarginine and symmetric dimethylarginine concentrations were determined simultaneously by high-performance liquid chromatography. Endothelium-dependent brachial artery flow-mediated dilation (FMD) was measured by ultrasound. The serum L-homoarginine concentration was significantly higher during the second and the third trimesters compared with the levels in the non-pregnant women (4.8+/-1.7 and 5.3+/-1.5 vs 2.7+/-1.0 micromol/L, p<0.001, respectively). In line with this, FMD increased in response to pregnancy (p<0.05). Three months after delivery, the L-homoarginine concentrations and FMD were comparable to those recorded in the non-pregnant females. The concentration of L-homoarginine correlated significantly with gestational age (r=0.426, p=0.001) and brachial artery diameter and FMD (r=0.362, p=0.006 and r=0.306, p=0.022, respectively) in pregnancy. CONCLUSIONS: L-homoarginine appears to be increased during the second and third trimesters of pregnancy and may contribute to the enhanced endothelial function in normal pregnancies.
Pirjo Valtonen; Tomi Laitinen; Tiina Lyyra-Laitinen; Olli T Raitakari; Markus Juonala; Jorma S A Viikari; Nonna Heiskanen; Esko Vanninen; Kari Punnonen; Seppo Heinonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-24     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1879-84     Citation Subset:  IM    
Laboratory Centre, Department of Clinical Chemistry, Kuopio University Hospital and University of Kuopio, Kuopio, Finland.
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MeSH Terms
Blood Flow Velocity / physiology
Endothelium, Vascular / metabolism*
Homoarginine / blood*
Nitric Oxide / blood*
Vasodilation / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 156-86-5/Homoarginine

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