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Serum IgG4 was Associated with the number and the distribution of the extrapancreatic lesions in type 1 Autoimmune Pancreatitis Patients.
MedLine Citation:
PMID:  21929654     Owner:  NLM     Status:  Publisher    
Background and Aim. Type 1 Autoimmune pancreatitis (AIP) is characterized by the increase of serum IgG4 and abundant IgG4 plasma cell infiltration in pancreas and various extrapancreatic lesions (EPL) which are proposed as IgG4-related disease. We assessed the correlation between serum IgG4 and the number of EPLs, and the association between serum IgG4 and the distribution of EPLs in type 1 AIP patients. Methods. Serum IgG4 was measured in 35 type 1 AIP patients and 71 non-AIP patients. The clinical characteristics and distribution of 8 EPLs were determined in 35 type 1 AIP patients. Results. Serum IgG4 in type 1 AIP was significantly higher than in non-AIP (p < 0.001). 33 patients have EPLs among 35 patients of type 1 AIP (94.3 %). There was a significant correlation between serum IgG4 and the number of EPLs. (ρ= 0.75, p < 0.001) Further, to assess the association between serum IgG4 and the distribution of EPL, type 1 AIP patients were divided into two groups as abdominal localized EPL and systemic EPL. Both serum IgG4 and total numbers of EPL in systemic EPL was remarkably higher than those in abdominal localized EPL. Serum IgG4 cutoff value was 346 mg/dl to distinguish between abdominal localized EPL and systemic EPL by the ROC curve data. Conclusions. Our findings indicated that serum IgG4 was useful in both the diagnosis of type 1 AIP and the detection of systemic EPLs. Our finding may help the concept and diagnostic criteria of IgG4-related disease with type 1 AIP.
Ryohei Kaji; Hidetoshi Takedatsu; Yoshinobu Okabe; Yusuke Ishida; Gen Sugiyama; Koji Yonemoto; Keiichi Mitsuyama; Osamu Tsuruta; Michio Sata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine Biostatistics Center, Kurume University Address: 67 Asahi-machi Kurume, Fukuoka 830-0011, Japan Tel: +81-942-35-3311 Ext. 3714 Fax: +81-942-34-2623.
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