Document Detail

Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura.
MedLine Citation:
PMID:  2702774     Owner:  NLM     Status:  MEDLINE    
Serum IgG subclass levels were investigated in 27 IgA GN and HSP patients and 19 healthy paired controls using a panel of monoclonal antibodies. IgG1 and IgG2 were statistically lower than in the controls in both the non-nephrotic and nephrotic patients, and 80% of the non-nephrotic patients exhibited a partial deficiency for either IgG1, IgG2 or IgG3. Urinary losses of IgG only accounted for decreased levels of IgG4. Fifty-four percent of these patients exhibited decreased IgM levels. This IgG-IgM imbalance may increase the susceptibility of these patients to viral and bacterial infections of the upper respiratory tract and trigger the renal disease. These findings raise the hypothesis that this IgG-IgM imbalance might be involved in the etiopathogenesis of these diseases.
G Rostoker; M A Pech; S Del Prato; M Petit-Phar; A Ben Maadi; J M Dubert; P Lang; B Weil; G Lagrue
Related Documents :
2329414 - Regional variation in c4 phenotype in patients with iga nephropathy.
3873974 - Complement activation in the adult respiratory distress syndrome following cardiopulmon...
646464 - Immunological studies in frozen shoulder.
751324 - Immune deficiency, thrombocytopenia and osteomyelitis in pediatric patients.
2667304 - Effectiveness of intravenous propafenone for conversion of atrial fibrillation and flut...
8888814 - Langerhans cell histiocytosis in the adult.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  75     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-05-22     Completed Date:  1989-05-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  30-4     Citation Subset:  IM    
Department of Nephrology, INSERM U 139, Centre Claude Bernard, Hôpital Henri Mondor, Créteil, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glomerulonephritis, IGA / immunology*
Immunoglobulin G / metabolism*,  urine
Immunoglobulin M / metabolism*
Middle Aged
Nephrotic Syndrome / immunology
Purpura, Schoenlein-Henoch / immunology*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Demonstration of anti-idiotypic antibodies directed against IgM rheumatoid factor in the serum of rh...
Next Document:  Enhanced IgG1 and IgG3 responses to pneumococcal polysaccharides in isolated IgA deficiency.