Document Detail

Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura.
MedLine Citation:
PMID:  2702774     Owner:  NLM     Status:  MEDLINE    
Serum IgG subclass levels were investigated in 27 IgA GN and HSP patients and 19 healthy paired controls using a panel of monoclonal antibodies. IgG1 and IgG2 were statistically lower than in the controls in both the non-nephrotic and nephrotic patients, and 80% of the non-nephrotic patients exhibited a partial deficiency for either IgG1, IgG2 or IgG3. Urinary losses of IgG only accounted for decreased levels of IgG4. Fifty-four percent of these patients exhibited decreased IgM levels. This IgG-IgM imbalance may increase the susceptibility of these patients to viral and bacterial infections of the upper respiratory tract and trigger the renal disease. These findings raise the hypothesis that this IgG-IgM imbalance might be involved in the etiopathogenesis of these diseases.
G Rostoker; M A Pech; S Del Prato; M Petit-Phar; A Ben Maadi; J M Dubert; P Lang; B Weil; G Lagrue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  75     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-05-22     Completed Date:  1989-05-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  30-4     Citation Subset:  IM    
Department of Nephrology, INSERM U 139, Centre Claude Bernard, Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
Glomerulonephritis, IGA / immunology*
Immunoglobulin G / metabolism*,  urine
Immunoglobulin M / metabolism*
Middle Aged
Nephrotic Syndrome / immunology
Purpura, Schoenlein-Henoch / immunology*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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