| Serum IgG repertoire in clinically isolated syndrome predicts multiple sclerosis. | |
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MedLine Citation:
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PMID: 19299435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We previously showed that serum IgG repertoires distinguished multiple sclerosis (MS) patients from healthy subjects and from patients with other inflammatory neurological diseases (OIND). We questioned whether the serum IgG repertoire of patients presenting a clinically isolated syndrome (CIS) could predict MS. METHODS: The global IgG immune responses against brain antigens in sera from 50 CIS patients were evaluated by immunoblotting. The IgG reactivities were compared with those from MS sera (n = 82), healthy sera (n = 27), and sera from OIND (n = 42). A linear discriminant analysis (LDA) defined a score for each individual. RESULTS: About 78% of scores obtained from CIS patients were located in the "MS area." During the follow-up (3.5 +/- 1.3 years), 28 patients fulfilled the McDonald criteria for MS, 15 patients remained CIS, and 7 patients developed OIND. Among the patients with an LDA score in the "MS area," 61.5% converted to MS. DISCUSSION: Our results suggest that a pathological distortion of the self-reactive IgG repertoire occurs early so that immunomodulating treatment should be started as early as possible; they also highlight the early involvement of B cells in the physiopathological process in MS. |
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Authors:
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H Zéphir; D Lefranc; S Dubucquoi; J de Seze; L Boron; L Prin; P Vermersch |
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Publication Detail:
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Type: Journal Article Date: 2009-03-19 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 15 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 593-600 Citation Subset: IM |
Affiliation:
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Pôle Neurologique, Hôpital Roger Salengro, CHRU de Lille, Lille, France; Laboratoire d'Immunologie, EA 2686, Université de Lille II, Lille, France. h-zephir@chru-lille.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Specificity B-Lymphocytes / immunology* Biological Markers / blood* Brain / immunology Female Humans Immunoglobulin G / blood* Male Multiple Sclerosis / epidemiology*, immunology* Nerve Tissue Proteins / immunology Predictive Value of Tests Risk Factors Seroepidemiologic Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunoglobulin G; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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