Document Detail


Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis.
MedLine Citation:
PMID:  20568382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although associated allergies are common and the mechanism may include long-term exposure to allergens, measurement of serum specific IgE levels has not been studied in pediatric eosinophilic esophagitis (EE).
OBJECTIVE: To compare the results of serum IgE testing, patch testing, and epicutaneous skin testing to measure allergic sensitization in pediatric patients with EE.
METHODS: In a cross-sectional study of 53 pediatric patients with EE, relevant history was obtained by questionnaire, and patch testing to foods was performed. Food and inhalant sensitivities were also assessed using skin prick testing and serum specific IgE measurement. Streptavidin CAP was used to measure specific IgE to cross-reactive carbohydrate determinants and Helicobacter pylori.
RESULTS: The overall prevalence of food and inhalant sensitization was 80%, with higher total IgE levels in sensitized vs nonsensitized patients (median, 150 vs 13 IU/mL; P < .001). For foods, serum IgE measurement detected more positive results than did skin prick testing. Specific IgE to milk was most common (43%). Inhalants were implicated as frequently as were foods. In keeping with this, 32% of patients had a cluster of multiple sensitivities that included pollens, soy, grains, peanut, and tree nuts and had higher total IgE levels (P = .001). Patch test results were interpreted as positive in 39% of patients (rye, wheat, and soy were the most common).
CONCLUSIONS: Most, but not all, patients with EE are highly atopic individuals with frequent allergic sensitivities. Thus, serum IgE measurement of low-titer IgE antibody may be useful in identifying relevant food sensitivities and in distinguishing subgroups of patients with EE, making a more directed approach to food avoidance possible.
Authors:
Elizabeth A Erwin; Hayley R James; Heather M Gutekunst; John M Russo; Kelly J Kelleher; Thomas A E Platts-Mills
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  104     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-08     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  496-502     Citation Subset:  IM    
Affiliation:
Center for Innovation in Pediatric Practice, Nationwide Children's Hospital, Columbus, Ohio 43205, USA. eae9m@virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Carbohydrates / immunology
Child
Child, Preschool
Cross Reactions
Cross-Sectional Studies
Eosinophilia / immunology*
Esophagitis / immunology*
Female
Food Hypersensitivity / diagnosis*
Humans
Immunoglobulin E / blood*
Infant
Male
Skin Tests
Grant Support
ID/Acronym/Agency:
K23 AI059317-01A2/AI/NIAID NIH HHS; K23AI059317/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Carbohydrates; 37341-29-0/Immunoglobulin E
Comments/Corrections

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