Document Detail


Serum IgE levels and reaginic-type skin reactions in sarcoidosis.
MedLine Citation:
PMID:  810284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunoglobulin E (IgE) levels in sera of eighty-four patients with sarcoidosis and fifty-one apparently healthy controls were measured by means of a radioimmunosorbent test (RIST). A significant decrease in IgE level was commonly seen in patients with sarcoidosis. In some patients, a typical isolated IgE deficiency was noted. In a group of patients with significantly low serum IgE levels, reduced immune responsiveness affecting the IgE class was suggested from the study on reaginic-type skin reactions. The implication of these findings with respect to the immunology and etiology of sarcoidosis is discussed.
Authors:
T Yagura; M Shimizu; Y Yamamura; T Tachibana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  21     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-01-23     Completed Date:  1976-01-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / administration & dosage
Antibodies / administration & dosage*
Antibody Formation
Female
Humans
Immune Sera / administration & dosage
Immunodiffusion
Immunoglobulin A / analysis
Immunoglobulin E / analysis*
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Injections, Intradermal
Male
Middle Aged
Radioimmunoassay
Reagins / administration & dosage*
Sarcoidosis / immunology*
Skin Tests*
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies; 0/Immune Sera; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Reagins; 37341-29-0/Immunoglobulin E
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