Document Detail

Serum IL-8 levels and localization of IL-8 in liver from patients with chronic viral hepatitis.
MedLine Citation:
PMID:  9840119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Interleukin 8 is known as a chemotactic factor for neutrophils and T cells. Such inflammatory cells are observed in the liver tissue in chronic viral hepatitis. However, it is not known whether interleukin 8 relates to hepatic injury in patients with chronic viral hepatitis. Therefore, we determined serum interleukin 8 levels and identified the cells related to interleukin 8 production in liver tissue. METHODOLOGY: Studies were performed on 29 patients with chronic viral hepatitis and 20 normal controls. Serum interleukin 8 levels were assayed using a sandwich ELISA. Immunohistochemical examination was performed to identify the cells related to interleukin 8 production by using a rabbit polyvalent antibody to human interleukin 8. RESULTS: Serum interleukin 8 levels were found to be increased significantly (p<0.05) in patients with chronic viral hepatitis compared with normal controls. They were also increased significantly in patients with chronic active hepatitis compared with chronic persistent hepatitis (p<0.05), and during exacerbation stages compared with remission stages (p<0.05). Out of the 10 patients examined immunohistochemically, interleukin 8 positive cells in the liver tissue were visualized in 7 patients and observed mainly along sinusoids. There was significant correlation between serum interleukin 8 levels and intensity of staining for interleukin 8 in the liver tissue (p<0.05, r=0.869). CONCLUSIONS: Interleukin 8 plays a role in hepatic injury in patients with chronic viral hepatitis, and is mainly produced by nonparenchymal cells in the liver.
T Masumoto; K Ohkubo; K Yamamoto; T Ninomiya; M Abe; S M Akbar; K Michitaka; N Horiike; M Onji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  45     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1630-4     Citation Subset:  IM    
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Hepatitis B, Chronic / metabolism*
Hepatitis C, Chronic / metabolism*
Interleukin-8 / blood,  metabolism*
Liver / chemistry*
Reg. No./Substance:

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