Document Detail


Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten.
MedLine Citation:
PMID:  17597819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with dermatitis herpetiformis (DH) have a gluten-sensitive enteropathy and while on gluten-containing diets have elevated levels of serum IL-8. We hypothesized that the mucosal immune response to gluten is responsible for the elevated serum IL-8. Six DH patients were studied while on a gluten-free diet (GFD), whereas four continued on a normal diet. Patients were followed for a mean 2.2 years and serum IL-8 was analyzed. Small bowel biopsies from five DH patients on normal diets, two DH patients on GFD, and six subjects with no small bowel abnormalities were analyzed for IL-8 mRNA. Serum IL-8 levels normalized in five of six patients on GFD and decreased in one, whereas serum IL-8 levels showed no statistically significant change in DH patients on normal diets. Small bowel biopsies from DH patients on normal diets had increased expression of IL-8 mRNA compared to normal subjects, whereas patients on a GFD showed no significant increase in small bowel mRNA. No significant IL-8 mRNA was detected in normal skin biopsies from patients with DH. These observations suggest that the IL-8 in the serum of patients with DH originates from the small bowel as a mucosal immune response to gluten ingestion.
Authors:
Russell P Hall; Keith M Benbenisty; Clinzo Mickle; Fumiko Takeuchi; Robert D Streilein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-28
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  127     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2158-65     Citation Subset:  IM    
Affiliation:
Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham VA Medical Center, Durham, North Carolina 27710, USA. Hall0009@mc.duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Celiac Disease / diet therapy
Dermatitis Herpetiformis / blood*
Diet
Female
Glutens / metabolism*
Humans
Immunoglobulin A / chemistry
Interleukin-8 / blood*,  metabolism
Intestine, Small / metabolism
Male
Middle Aged
RNA, Messenger / metabolism
Grant Support
ID/Acronym/Agency:
5R0-1-AI-047258/AI/NIAID NIH HHS; 5R01-DK-050678/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Interleukin-8; 0/RNA, Messenger; 8002-80-0/Glutens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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