| Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten. | |
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MedLine Citation:
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PMID: 17597819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with dermatitis herpetiformis (DH) have a gluten-sensitive enteropathy and while on gluten-containing diets have elevated levels of serum IL-8. We hypothesized that the mucosal immune response to gluten is responsible for the elevated serum IL-8. Six DH patients were studied while on a gluten-free diet (GFD), whereas four continued on a normal diet. Patients were followed for a mean 2.2 years and serum IL-8 was analyzed. Small bowel biopsies from five DH patients on normal diets, two DH patients on GFD, and six subjects with no small bowel abnormalities were analyzed for IL-8 mRNA. Serum IL-8 levels normalized in five of six patients on GFD and decreased in one, whereas serum IL-8 levels showed no statistically significant change in DH patients on normal diets. Small bowel biopsies from DH patients on normal diets had increased expression of IL-8 mRNA compared to normal subjects, whereas patients on a GFD showed no significant increase in small bowel mRNA. No significant IL-8 mRNA was detected in normal skin biopsies from patients with DH. These observations suggest that the IL-8 in the serum of patients with DH originates from the small bowel as a mucosal immune response to gluten ingestion. |
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Authors:
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Russell P Hall; Keith M Benbenisty; Clinzo Mickle; Fumiko Takeuchi; Robert D Streilein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-06-28 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 127 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 2158-65 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham VA Medical Center, Durham, North Carolina 27710, USA. Hall0009@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Celiac Disease / diet therapy Dermatitis Herpetiformis / blood* Diet Female Glutens / metabolism* Humans Immunoglobulin A / chemistry Interleukin-8 / blood*, metabolism Intestine, Small / metabolism Male Middle Aged RNA, Messenger / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5R0-1-AI-047258/AI/NIAID NIH HHS; 5R01-DK-050678/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Interleukin-8; 0/RNA, Messenger; 8002-80-0/Glutens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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