Document Detail

Serum IL-8 and MCP-1 concentration do not identify patients with enlarging contusions after traumatic brain injury.
MedLine Citation:
PMID:  19509619     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cerebral contusions contain numerous leukocytes, and a temporal relationship exists among cerebral chemokine expression, leukocyte recruitment, and contusion enlargement. This would suggest a role for chemokines in contusion development. However, it has not been established if serum concentrations of chemokines such as interleukin-8 (IL-8) or monocyte chemoattractant protein-1 (MCP-1) change with contusion enlargement. METHODS: Eighteen adult patients with severe contusional traumatic brain injury, on computerized tomography, were identified. Patients with diffuse injuries or extradural and subdural hematomas associated with mass effect were not included in the study. Daily serum samples were taken for the measurement of IL-8 and MCP-1 concentrations for up to 11 days postinjury. RESULTS: In the patients who died while in intensive care, IL-8 and MCP-1 were significantly greater than in those patients discharged (18 [0-202] vs. 0 [0-156] pg/mL and 498 [339-1,063] vs. 368 [86-11,289] pg/mL for IL-8 and MCP-1, respectively). No difference was seen in serum chemokine levels in patients who deteriorated with contusion enlargement compared with those that did not. The IL-8 and MCP-1 concentrations did not change significantly over time either in the group as a whole or in the subgroup of patients who deteriorated. CONCLUSIONS: These inflammatory mediators may be predictive of a poor outcome in patients with traumatic brain injury in which contusions are the predominant abnormality. However, they do not distinguish those patients who will deteriorate because of contusion enlargement.
Jonathan Rhodes; John Sharkey; Peter Andrews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  66     ISSN:  1529-8809     ISO Abbreviation:  J Trauma     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1591-7; discussion 1598     Citation Subset:  AIM; IM    
Department of Anaesthesia, Critical Care and Pain Medicine, Western General Hospital, University of Edinburgh, Edinburgh, Scotland.
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MeSH Terms
Brain Injuries / blood*,  complications*,  etiology
Chemokine CCL2 / blood*
Disease Progression
Interleukin-8 / blood*
Middle Aged
Young Adult
Reg. No./Substance:
0/Chemokine CCL2; 0/Interleukin-8

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