| Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke. | |
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MedLine Citation:
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PMID: 21508132 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context and Objective: GH has positive cognitive effects when given to GH-IGF-I-deficient patients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke. Subjects and Methods: The s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke. Results: The s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively). Conclusion: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function. |
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Authors:
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Daniel Aberg; Katarina Jood; Christian Blomstrand; Christina Jern; Michael Nilsson; Jörgen Isgaard; N David Aberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Experimental Endocrinology (D.Å., J.I., N.D.Å.), Department of Internal Medicine, and Department of Clinical Genetics (C.J.), Sahlgrenska University Hospital; and Center of Brain Repair and Rehabilitation (M.N., N.D.Å.), Institute of Neuroscience and Physiology (K.J., C.B.), The Sahlgrenska Academy at University of Gothenburg, SE-413 45 Göteborg, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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