Document Detail

Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke.
MedLine Citation:
PMID:  21508132     Owner:  NLM     Status:  Publisher    
Context and Objective: GH has positive cognitive effects when given to GH-IGF-I-deficient patients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke. Subjects and Methods: The s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke. Results: The s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively). Conclusion: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function.
Daniel Aberg; Katarina Jood; Christian Blomstrand; Christina Jern; Michael Nilsson; Jörgen Isgaard; N David Aberg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Experimental Endocrinology (D.Å., J.I., N.D.Å.), Department of Internal Medicine, and Department of Clinical Genetics (C.J.), Sahlgrenska University Hospital; and Center of Brain Repair and Rehabilitation (M.N., N.D.Å.), Institute of Neuroscience and Physiology (K.J., C.B.), The Sahlgrenska Academy at University of Gothenburg, SE-413 45 Göteborg, Sweden.
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