| Serum IGF-1 in treated acromegaly - how normal is "normal"? | |
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MedLine Citation:
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PMID: 16379035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe four acromegalic patients with persisting typical symptoms - excessive sweating, lack of suppleness of hands, joint pains - despite the achievement of normal serum IGF-1 levels after pituitary surgery. In three patients there was a clear improvement in symptoms when lower IGF-1 levels within the normal range were achieved with pegvisomant treatment. In the fourth patient IGF-1 levels have fluctuated within the normal range with persistence of abnormal sweating, particularly at night. Two of three patients who had an oral glucose tolerance test when serum IGF-1 was in the normal range failed to suppress GH levels to less than 1 ng/ml. We conclude that, in the treated acromegalic patient, IGF-1 levels within the normal range need to be looked at critically to determine what is truly normal for that individual. Relief of symptoms seems a reasonable yardstick, in addition to population norms, by which to judge whether the prevailing IGF-1 level is appropriate; in some cases the aim should be an IGF-1 level in the lower half of the normal range, or perhaps even the lowest quartile. |
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Authors:
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Cecilia Lansang; Nikoloz Chitaia; Nicholas E Simpson; Laurence Kennedy |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pituitary Volume: 8 ISSN: 1386-341X ISO Abbreviation: Pituitary Publication Date: 2005 |
Date Detail:
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Created Date: 2006-02-27 Completed Date: 2006-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814578 Medline TA: Pituitary Country: United States |
Other Details:
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Languages: eng Pagination: 135-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Department of Medicine, University of Florida, Gainesville, FL 32610-0226, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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blood*,
therapy Adult Female Human Growth Hormone / analogs & derivatives, therapeutic use Humans Insulin-Like Growth Factor I / analysis* Male Middle Aged Reference Values |
| Chemical | |
Reg. No./Substance:
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0/pegvisomant; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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