Document Detail

Serum IGF-1 in treated acromegaly - how normal is "normal"?
MedLine Citation:
PMID:  16379035     Owner:  NLM     Status:  MEDLINE    
We describe four acromegalic patients with persisting typical symptoms - excessive sweating, lack of suppleness of hands, joint pains - despite the achievement of normal serum IGF-1 levels after pituitary surgery. In three patients there was a clear improvement in symptoms when lower IGF-1 levels within the normal range were achieved with pegvisomant treatment. In the fourth patient IGF-1 levels have fluctuated within the normal range with persistence of abnormal sweating, particularly at night. Two of three patients who had an oral glucose tolerance test when serum IGF-1 was in the normal range failed to suppress GH levels to less than 1 ng/ml. We conclude that, in the treated acromegalic patient, IGF-1 levels within the normal range need to be looked at critically to determine what is truly normal for that individual. Relief of symptoms seems a reasonable yardstick, in addition to population norms, by which to judge whether the prevailing IGF-1 level is appropriate; in some cases the aim should be an IGF-1 level in the lower half of the normal range, or perhaps even the lowest quartile.
Cecilia Lansang; Nikoloz Chitaia; Nicholas E Simpson; Laurence Kennedy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pituitary     Volume:  8     ISSN:  1386-341X     ISO Abbreviation:  Pituitary     Publication Date:  2005  
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Division of Endocrinology, Department of Medicine, University of Florida, Gainesville, FL 32610-0226, USA.
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MeSH Terms
Acromegaly / blood*,  therapy
Human Growth Hormone / analogs & derivatives,  therapeutic use
Insulin-Like Growth Factor I / analysis*
Middle Aged
Reference Values
Reg. No./Substance:
0/pegvisomant; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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