Document Detail

Serum IGF-1 concentrations change with soy and seaweed supplements in healthy postmenopausal American women.
MedLine Citation:
PMID:  21711174     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factor 1 (IGF-1) is an anabolic hormone important for growth and development. However, high-circulating serum concentrations in adults are associated with increased risk of postmenopausal breast cancer. Nutritional status and specific foods influence serum IGF-1 concentrations. Breast cancer incidence is typically low in Asian countries where soy is commonly consumed. Paradoxically, soy supplement trials in American women have reported significant increases in IGF-1. Seaweed also is consumed regularly in Asian countries where breast cancer risk is low. We investigated the possibility that seaweed could modify soy-associated increases in IGF-1 in American women. Thirty healthy postmenopausal women (mean age 58 yr) participated in this 14-wk double-blinded, randomized, placebo-controlled crossover clinical trial. Participants consumed 5 g/day placebo or seaweed (Alaria esculenta) in capsules for 7 wk. During the 7th wk, a high-soy protein isolate powder was added (2 mg/kg body weight aglycone equivalent isoflavones). Overnight fasting blood samples were collected after each intervention period. Soy significantly increased serum IGF-1 concentrations compared to the placebo (21.2 nmol/L for soy vs. 16.9 nmol/L for placebo; P = 0.0001). The combination of seaweed and soy significantly reduced this increase by about 40% (21.2 nmol/L for soy alone vs. 19.4 nmol/L; P = 0.01). Concurrent seaweed and soy consumption may be important in modifying the effect of soy on IGF-1 serum concentrations.
Jane Teas; Mohammad R Irhimeh; Susan Druker; Thomas G Hurley; James R Hébert; Todd M Savarese; Mindy S Kurzer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-06-28
Journal Detail:
Title:  Nutrition and cancer     Volume:  63     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-19     Completed Date:  2011-12-12     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-8     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Breast Neoplasms / epidemiology,  prevention & control
Cross-Over Studies
Dietary Supplements* / adverse effects
Double-Blind Method
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / analysis*
Massachusetts / epidemiology
Middle Aged
Phaeophyta / chemistry*
Postmenopause / blood*
Seaweed / chemistry*
Seeds / chemistry
Soybeans / chemistry*
Grant Support
K05 CA136975/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; K05 CA136975-02/CA/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Capsules; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I

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