Document Detail

Serum Hepcidin and Ferritin to Iron Ratio in Evaluation of Bacterial versus Viral Infections in Children: A Single Center Study.
MedLine Citation:
PMID:  22531233     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Differential diagnosis of childhood infections is important. Several biochemical indices steer diagnosis towards bacterial agents, although the data are often not definitive. Hepcidin is a central component of blood iron and ferritin alterations occur during infections. We measured hepcidin changes and evaluated ferritin to iron ratio(FIR) in patients with suspected infections. METHODS:: We studied 69 children with infection and an equal number of matched controls during a 3 year period. A bacterial agent was demonstrated in 17 and a viral pathogen in 52 of the patients. Hematologic and biochemical tests were performed in all children including ferritin, iron and hepcidin. FIR was calculated and receiver operating characteristic (ROC) curve analysis was performed to evaluate the best FIR cutoff value to discriminate between patients and controls and between patients with bacterial and viral infections. RESULTS:: Hepcidin, ferritin and FIR were significantly higher and iron values significantly lower in febrile patients than its controls. Patients with bacterial infection had significantly lower iron and higher FIR than those with viral infection. FIR had high accuracy discriminating patients from controls, but only moderate accuracy discriminating bacterial from viral infected patients. CONCLUSIONS:: If further studies with larger samples confirm these observations, FIR could be used as an inexpensive, rapid and easily performed complementary index for diagnosis of bacterial infections.
Kossiva Lydia; Gourgiotis I Dimitrios; Tsentidis Charalampos; Anastasiou Theodora; Marmarinos Antonis; Vasilenko Helen; Sdogou Triantafyllia; Georgouli Helen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Second Department of Pediatrics 'P&A Kyriakou' Children's Hospital, Medical School, Athens University 2ILaboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics 'P&A Kyriakou' Children's Hospital, Medical School, Athens University 3Laboratory of Hematology, 'P&A Kyriakou' Children's Hospital, Athens.
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