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Serum HCG measured in the peri-implantation period predicts IVF cycle outcomes.
MedLine Citation:
PMID:  22818096     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The current study assessed the relationship between serum concentrations of human chorionic gonadotrophin (HCG) measured in the peri-implantation period and various outcome measures following blastocyst transfer in IVF cycles. The study group included 767 autologous IVF cycles, each with the transfer of two fresh blastocysts in a 6-year study period, ending 31 December 2009. Outcome measures were ectopic pregnancy, biochemical pregnancy loss, ongoing pregnancy, spontaneous abortion and multiple pregnancy. Peri-implantation serum HCG concentration measured 5days after blastocyst transfer was highly predictive of these outcome measures. These findings suggest embryonic implantation and developmental fate are largely determined by 5days after blastocyst transfer and that very early serum HCG measurements may be useful markers of IVF outcome.
Authors:
Bruce S Shapiro; Said T Daneshmand; Humberto Restrepo; Forest C Garner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  -     ISSN:  1472-6491     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Fertility Center of Las Vegas, 8851 W. Sahara Avenue, Las Vegas, NV 89117, USA; Department of Obstetrics and Gynecology, University of Nevada, School of Medicine, 2040 W. Charleston Blvd Ste. 200, Las Vegas, NV 89102, USA.
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