| Serum EPO and VEGF levels in patients with sleep-disordered breathing and acute myocardial infarction. | |
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MedLine Citation:
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PMID: 23340852 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: A high level of endogenous erythropoietin (EPO) may be associated with a smaller infarct size determined by the release of necrosis markers. Sleep-disordered breathing (SDB) is a well-known risk factor for cardiovascular diseases. In contrast, protective effects of SDB have also been described. The potential role of increased levels of EPO and vascular endothelial growth factor (VEGF) is suggested in this process. The study aimed to explore the EPO and VEGF serum levels in SDB and non-SDB patients during the acute phase of myocardial infarction. METHODS: Thirty-seven patients undergoing successful primary percutaneous coronary intervention in the acute myocardial infarction have been examined for the levels of EPO, VEGF, and troponin I (Tn). In the following, patients had an overnight polysomnography to determine breathing disturbances during sleep. RESULTS: Both on admission day (day 1) and day 3 of hospitalization, EPO levels showed statistically significant differences in both SDB-positive and SDB-negative patient groups (p = 0.003 and p = 0.018, respectively). There was no statistically significant difference in VEGF levels. No correlation was found between the EPO and Tn levels. CONCLUSIONS: SDB patients tend to have higher levels of EPO during acute myocardial infarction. No statistically significant differences in VEGF levels were observed. |
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Authors:
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Wojciech Kukwa; Renata Glowczynska; Krzysztof J Filipiak; Andrzej Kukwa; Grzegorz Opolski; Anna Budaj-Fidecka; Marcin Grabowski; Adam Galazka; Antoni Krzeski; Monika Kuzminska; Anna M Czarnecka |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-23 |
Journal Detail:
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Title: Sleep & breathing = Schlaf & Atmung Volume: - ISSN: 1522-1709 ISO Abbreviation: Sleep Breath Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804161 Medline TA: Sleep Breath Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, 19/25 Stepinska Street, 00-739, Warsaw, Poland, wkukwa@yahoo.pl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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