Document Detail

Serum ECP taken in the acute episode of bronchial obstruction can predict the development of bronchial asthma in young children.
MedLine Citation:
PMID:  11332295     Owner:  NLM     Status:  MEDLINE    
For the early institution of anti-asthma treatment, reliable markers distinguishing the children with asthma from children with virus-associated wheeze are needed. Serum eosinophilic cationic protein (ECP) has been suggested as a marker correlating with the intensity of eosinophilic inflammation. We have studied 27 children (age 3 to 35 months) admitted with acute bronchial obstruction. Each child had been followed for 12 months after the first episode and then assigned to one of two groups (asthma or non-asthma) based on the clinical course. Serum ECP (s-ECP) was taken at the acute episode and again at least 6 months later, when the child was completely symptom-free. Serum ECP was analyzed using the Pharmacia CAP ECP FEIA immunofluorescence system. Mean s-ECP during the acute episode was 26.5 micrograms/L (5.5-69) in the asthma group (n = 14) and 9.7 (5.2-17 micrograms/L) in the non-asthmatics (n = 13), p < 0.01. There was no difference in the s-ECP analyzed during the symptom-free period. Elevated values of serum ECP taken during, but not outside, the acute episodes of bronchial obstruction may be helpful in predicting the development of bronchial asthma in young children with acute obstructive episodes.
P Pohunek; P Kucera; B Suková; F Votava; J Zikán
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  22     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Department of Pediatric Pulmonology, University Hospital Motol, Prague, Czech Republic.
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MeSH Terms
Asthma / etiology,  prevention & control*
Biological Markers / blood
Blood Proteins / analysis*
Bronchial Spasm / blood*,  complications
Child, Preschool
Eosinophil Granule Proteins
Fluorescent Antibody Technique
Follow-Up Studies
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

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