Document Detail

Serum DHAS in the maternal-fetoplacental system during the 28th-40th weeks of pregnancy.
MedLine Citation:
PMID:  2976004     Owner:  NLM     Status:  MEDLINE    
The authors measured the serum levels of dehydroepiandrosterone sulfate (DHAS) in the maternal vein (MV), the umbilical vein (UV) and the umbilical artery (UA) during the 28th-36th weeks of pregnancy (n = 74) and in the 40th week (n = 34), to clarify the hormonal changes that occur between the maternal and fetal compartments. The following results were found: (1) The DHAS concentration increased significantly in MV, up to twice the concentration from the 28th-32nd weeks to the 33rd-36th weeks (p less than 0.01). From the 33rd-36th weeks to the 40th week it decreased significantly to one third of this value (p less than 0.01). DHAS levels revealed a decreasing tendency in the UA and UV serum from the 28th-32nd weeks to the 33rd-36th weeks, and there was a tendency to rise from the 33rd-36th weeks to the 40th week. (2) The serum DHAS values were found to be higher than in the MV, the UA-UV difference was not significant; however, the 'UA/UV X 100' value remained higher than 100% during the 28th-40th weeks. (3) The MV DHAS value showed slight correlation with the UV and UA DHAS concentration (r = 0.2951, p less than 0.01, n = 106; r = 0.2930, p less than 0.01, n = 100). There was a close correlation between the UV and UA serum DHAS levels (r = 0.8432, p less than 0.01, n = 98). The authors consider that the adrenal activity increases independently of the maternal adrenal cortex at term.
P Hercz; L Ungár; P Siklós; R G Farquharson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  29     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-04-05     Completed Date:  1989-04-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Semmelweis Medical School, IInd Department of Obstetrics and Gynecology, Budapest, Hungary.
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MeSH Terms
Adrenal Cortex / metabolism*
Dehydroepiandrosterone / analogs & derivatives*,  biosynthesis,  blood
Dehydroepiandrosterone Sulfate
Estrogens / biosynthesis
Infant, Newborn
Maternal-Fetal Exchange*
Pregnancy / blood*
Pregnancy Trimester, Third
Umbilical Arteries
Umbilical Veins
Reg. No./Substance:
0/Estrogens; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate

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