| Serum cystatin C and the incidence of hypertension in type 1 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20885369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum cystatin has been shown to be associated with hypertension in the general population. Little is known on the relationship of serum cystatin C with the long-term hypertension incidence in persons with diabetes. We examined the association of serum cystatin C with the incidence of hypertension over a 15-year period in people with type 1 diabetes mellitus. METHODS: The 15-year cumulative incidence of hypertension was measured in Wisconsin Epidemiologic Study of Diabetic Retinopathy participants. Hypertension was defined as a systolic blood pressure (BP) of ≥140 mm Hg and/or a diastolic BP of ≥90 mm Hg and/or history of use of antihypertensive treatment. The relation of cystatin C and other risk factors to hypertension incidence was determined with generalized linear modeling with the complementary log-log link function. RESULTS: After controlling for age, gender, diabetes duration, body mass index (BMI), glycosylated hemoglobin, and baseline systolic and diastolic BP, the baseline serum cystatin C was associated with the 15-year cumulative incidence of hypertension (hazard ratio (HR) per mg/l of cystatin C: 3.43, and 95% confidence interval: 1.36, 8.63). CONCLUSIONS: These findings show a relationship of serum cystatin C with the incidence of hypertension in type 1 diabetes mellitus. The underlying biological processes remain to be determined. |
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Authors:
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Karine Sahakyan; Barbara E K Klein; Kristine E Lee; Michael Y Tsai; Ronald Klein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: American journal of hypertension Volume: 24 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-17 Completed Date: 2011-02-11 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, USA. sahakyan@epi.ophth.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Cystatin C / blood* Diabetes Mellitus, Type 1 / blood*, complications Female Glomerular Filtration Rate Humans Hypertension / epidemiology* Incidence Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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DK073217/DK/NIDDK NIH HHS; EY016379/EY/NEI NIH HHS; R01 DK073217-03/DK/NIDDK NIH HHS; R01 EY016379-04/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cystatin C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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