| Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease. | |
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MedLine Citation:
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PMID: 21617322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum heart-type fatty acid-binding protein (H-FABP) is widely applied as a marker of cardiac myocyte injury. Recently, it has been reported that levels of H-FABP are elevated in adult patients with chronic heart failure and thus provide useful prognostic information. The aim of the present study was to examine the relationships between serum H-FABP levels and pathophysiological characteristics in children and adolescents with congenital heart disease (CHD). METHODS AND RESULTS: Serum H-FABP levels were preoperatively and postoperatively measured in 238 consecutive patients with CHD aged 1-31 years. The relationships between H-FABP levels and severity of heart failure, circulatory status and laboratory data were cross-sectionally analyzed. Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively). Neither left ventricular ejection fraction nor B-type natriuretic peptide correlated with H-FABP levels. CONCLUSIONS: H-FABP could serve as a new monitoring tool to provide information that will guide the optimal therapy and management of CHD patients. |
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Authors:
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Yasunobu Hayabuchi; Miki Inoue; Noriko Watanabe; Miho Sakata; Tatsuya Ohnishi; Shoji Kagami |
Publication Detail:
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Type: Journal Article Date: 2011-05-27 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 75 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-25 Completed Date: 2011-11-18 Revised Date: 2012-01-09 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1992-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Tokushima, Tokushima, Japan. hayabuchi@clin.med.tokushima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Child Child, Preschool Creatine Kinase, MB Form / blood Creatinine / blood Cross-Sectional Studies Fatty Acid-Binding Proteins / blood* Heart Defects, Congenital / blood*, physiopathology Humans Infant Male Natriuretic Peptide, Brain / blood Prospective Studies Stroke Volume |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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