Document Detail


Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease.
MedLine Citation:
PMID:  21617322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Serum heart-type fatty acid-binding protein (H-FABP) is widely applied as a marker of cardiac myocyte injury. Recently, it has been reported that levels of H-FABP are elevated in adult patients with chronic heart failure and thus provide useful prognostic information. The aim of the present study was to examine the relationships between serum H-FABP levels and pathophysiological characteristics in children and adolescents with congenital heart disease (CHD).
METHODS AND RESULTS: Serum H-FABP levels were preoperatively and postoperatively measured in 238 consecutive patients with CHD aged 1-31 years. The relationships between H-FABP levels and severity of heart failure, circulatory status and laboratory data were cross-sectionally analyzed. Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively). Neither left ventricular ejection fraction nor B-type natriuretic peptide correlated with H-FABP levels.
CONCLUSIONS: H-FABP could serve as a new monitoring tool to provide information that will guide the optimal therapy and management of CHD patients.
Authors:
Yasunobu Hayabuchi; Miki Inoue; Noriko Watanabe; Miho Sakata; Tatsuya Ohnishi; Shoji Kagami
Publication Detail:
Type:  Journal Article     Date:  2011-05-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-18     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1992-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Tokushima, Tokushima, Japan. hayabuchi@clin.med.tokushima-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Child
Child, Preschool
Creatine Kinase, MB Form / blood
Creatinine / blood
Cross-Sectional Studies
Fatty Acid-Binding Proteins / blood*
Heart Defects, Congenital / blood*,  physiopathology
Humans
Infant
Male
Natriuretic Peptide, Brain / blood
Prospective Studies
Stroke Volume
Chemical
Reg. No./Substance:
0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine; EC 2.7.3.2/Creatine Kinase, MB Form

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